Mea Hana Hana 99% Purity White Powder Antitumor Polypeptide Pharma Grade Cancer Research MELITTIN CAS 20449-79-0

MELITTIN CAS 20449-79-0 Hoʻohana:

ʻO Melitin ka mea hana nui o ka bee venom.ʻO ka Beevenom kahi ʻano mea ʻawaʻawa a me ka ʻala ʻala i huna ʻia e nā ʻiʻo ʻawaʻawa o ka nalo hana a me nā kelepa mea kōkua.Ke uhai ʻia, hoʻokuʻu ʻia mai ka stinger.Ma waena o nā ʻāpana he nui o ka bee venom, ʻo melittin ka mea kiʻekiʻe loa, e helu ana ma kahi o 50% o ke kaumaha maloʻo o ka bee venom, a he kiʻekiʻe kāna hana olaola.ʻO Melittin kahi peptide laina i haku ʻia me 26 amino acids, me ke kaumaha molekala pili o 2849. He kiʻekiʻe ka hana olaola ʻo Melittin.Ua hōʻike ʻia nā haʻawina pharmacological o kēia manawa he anti-inflammatory, analgesic, inhibiting platelet aggregation, anti-AIDS a me nā hopena ʻē aʻe he nui.Hiki i ka Melittin ke hana i ka hopena pepehi ikaika ma nā ʻano ʻokoʻa ʻokoʻa ma o nā ʻano hana like ʻole, a he lāʻau lapaʻau maoli ʻo ia ka anti-tumor.

Hiki i ka Melittin ke pale i ka ulu a me ka hana hou ʻana o nā ʻano he 20 o ka Gram-positive a me ka maikaʻi maikaʻi ʻole, a hiki ke hoʻonui i ka pono antibacterial o sulfonamides a me nā penicillins.Hoʻopau ʻo Melittin i ka membrane cell bacteria ma ka hoʻopaʻa ʻana i ka membrane e hoʻokō i ke kumu o ka bacteriolysis.Hiki i ka melittin a me kāna mau mea ʻeono ke hoʻololi i ka hana o nā lymphocytes T i loaʻa i ka maʻi HIV, kaohi i ka hana hou ʻana o ka maʻi HIV, a hoʻemi i ka maʻi o ka maʻi.

1. Ua hōʻoia ʻia ka hopena pepehi pololei In vitro ʻike ʻia ka melittin i ka hopena pepehi i nā laina cell tumor like ʻole e like me ka osteosarcoma, ka maʻi ovarian, a me ka glioma, a ua hoʻopili maikaʻi ʻia ka hopena pepehi me ka nui.Hiki i ka Melittin ke pepehi i nā pūnaewele maʻi a pale i ka ulu ʻana o nā pūnaewele maʻamau, a ʻaʻohe hopena i ʻike ʻia i ka ulu ʻana o nā cell maʻamau.Hiki iā Melittin ke hoʻokomo i loko o ka membrane cell o nā pūnaewele K562, hana i nā pores, hoʻoikaika i ka Ca2 + inflow, hoʻonui i ka ʻike o Ca2 + i loko o nā cell, hana i ka cell lysis, a pepehi pololei i nā cell K562.Ke manaʻoʻiʻo ʻia ʻo ka melittin e hoʻopau i ka membrane mitochondrial o nā cell, kaohi i ka hana hanu maʻamau o nā ʻōpū tumo, e hoʻopau i kā lākou aerobic respiration hiki, ke kāohi i ka ulu ʻana o ka ʻiʻo maʻi maʻi, a pepehi pololei i nā cell tumor.
2. ʻO ka hopena immunomodulatory He mea pale nui ke kino o ke kino mai nā maʻi maʻi a me nā maʻi viral.He kuleana koʻikoʻi ke kūlana o ke kino o ke kino i ka hana ʻana a me ka ulu ʻana o nā maʻi maʻi.Hiki i ka hoʻonui ʻana i ka hana pale pale kelepona ke pāʻani i kekahi hopena anti-tumor.
3. ʻO ka hoʻokomo ʻana i ka apoptosis cell tumo Apoptosis, ʻike ʻia hoʻi ʻo ka make cell programmed, kahi kaʻina hana biological cell active i mālama ʻia e nā ʻano genes.No laila, ʻo ka apoptosis kahi kaʻina hana, e pili ana i ka hoʻoulu ʻana, ka ʻōlelo a me ka hoʻoponopono ʻana o nā ʻano genes.Ua hōʻike ʻia nā haʻawina o kēia manawa he nui nā lāʻau chemotherapeutic hiki ke hoʻokō i nā kumu therapeutic ma o ka hoʻoulu ʻana i ka apoptosis i loko o nā maʻi kanesa.ʻO ka hoʻoulu ʻana i ka apoptosis i lilo i mea hoʻohālikelike no ka nānā ʻana i nā lāʻau anticancer.

Hiki i ka Melittin ke kāohi i ka hana o ka sPLA2 mai nā kumu like ʻole, a hiki i ka 96% ka inhibition rate o ka hana sPLA2 i ka wai synovial o nā maʻi RA.No laila, hiki i ka hoʻohana ʻana i ka melittin ke hōʻoluʻolu i ka ulu ʻana o RA.

Hiki i ka sub-dose melittin ke hoʻemi nui i ka helu lysis o ka hoʻopiha i nā cell.Pili paha kēia mea pale me ka melittin e hoʻolaha ana i ka Ca2+ influx, hoʻoulu i ka ʻōnaehana transduction hōʻailona intracellular a me ka synthesis protein pale.Manaʻo ʻia ʻo ka hoʻohana ʻana i ka nui kūpono o ka melittin he waiwai lapaʻau i ka mālama ʻana iā RA e Chemicalbook.I nā makahiki i hala iho nei, ua hōʻike ʻia nā haʻawina e hiki ke hoʻopili i nā ʻano ʻokoʻa like ʻole o ka melittin i nā hana kelepona ma o nā ala like ʻole a hoʻohana i nā ʻano hopena olaola.ʻO ka noi kūpono o ka melittin e hāʻawi i nā lāʻau lapaʻau hou no kekahi mau maʻi.