Zopanga Zopanga 99% Purity White Powder Antitumor Polypeptide Pharma Gulu la Cancer Research MELITTIN CAS 20449-79-0

MELITTIN CAS 20449-79-0 Kugwiritsa Ntchito:

Melitin ndiye chinthu chachikulu chomwe chimagwiritsidwa ntchito popanga utsi wa njuchi.Beevenom ndi mtundu wa utsi wowonekera ndi fungo lonunkhira bwino lotulutsidwa ndi tiziwalo timene timatulutsa utsi wa njuchi ndi tiziwalo timene timatulutsa.Ikaphwanyidwa, imatulutsidwa ku mbola.Pakati pa zigawo zambiri za utsi wa njuchi, melittin imakhala ndi zinthu zambiri, zomwe zimawerengera pafupifupi 50% ya kulemera kowuma kwa utsi wa njuchi, ndipo imakhala ndi zochitika zambiri zamoyo.Melittin ndi mzere wa peptide wopangidwa ndi 26 amino acid, wokhala ndi molekyulu wolemera wa 2849. Melittin ali ndi zochita zambiri zamoyo.Maphunziro amakono a zamankhwala asonyeza kuti ali ndi anti-yotupa, analgesic, inhibiting platelet aggregation, anti-AIDS ndi zina zambiri.Melittin amatha kupha kwambiri ma cell a chotupa kudzera m'njira zosiyanasiyana, ndipo ndi mankhwala achilengedwe oletsa chotupa.

Melittin imatha kulepheretsa kukula ndi kubereka kwa mitundu yopitilira 20 ya mabakiteriya a gram-positive ndi negative, komanso imatha kukulitsa mphamvu ya antibacterial ya sulfonamides ndi penicillin.Melittin amawononga nembanemba yama cell a bakiteriya pomanga nembanemba kuti akwaniritse cholinga cha bacteriolysis.Melittin ndi zotumphukira zake zisanu ndi chimodzi zimatha kusintha magwiridwe antchito a T lymphocyte omwe ali ndi kachilombo ka HIV, kuletsa kubwerezabwereza kwa HIV, ndikuchepetsa kufalikira kwa kachilomboka.

1. Kupha kwachindunji Kuyesa kwa In vitro kwatsimikizira kuti melittin ili ndi zotsatira zowonekera bwino pama cell a chotupa monga osteosarcoma, khansa ya ovarian, ndi glioma, ndipo kupha kumayenderana ndi mlingo.Melittin amatha kupha maselo otupa ndikuletsa kukula kwa maselo otupa, ndipo alibe zotsatira zowonekera pakukula kwa maselo abwinobwino.Melittin imatha kuyika mu cell membrane ya maselo a K562, kupanga pores, kulimbikitsa kulowa kwa Ca2 +, kuonjezera kuchuluka kwa Ca2 + m'maselo, kumayambitsa cell lysis, ndikupha mwachindunji ma cell a K562.Amakhulupirira kuti melittin amasungunula nembanemba ya mitochondrial ya maselo, amalepheretsa kupuma kwabwino kwa maselo otupa, amawononga kupuma kwawo kwa aerobic, amalepheretsa kukula kwa chotupa, ndipo amapha mwachindunji maselo otupa.
2. Immunomodulatory effect Chitetezo cha mthupi ndichofunikira kwambiri pakuteteza thupi ku zotupa ndi ma virus.Mkhalidwe wa thupi ma chitetezo ntchito mbali yofunika kwambiri pa zochitika ndi chitukuko cha zotupa.Kupititsa patsogolo chitetezo chamthupi cha ma cell kumatha kukhala ndi anti-chotupa.
3. Kulowetsedwa kwa chotupa cell apoptosis Apoptosis, yomwe imadziwikanso kuti kufa kwadongosolo la cell, ndi njira yokhazikika yachilengedwe yama cell yomwe imayendetsedwa ndi mitundu yosiyanasiyana ya majini.Choncho, apoptosis ndi njira yogwira ntchito, yomwe imaphatikizapo kuyambitsa, kufotokozera ndi kulamulira mndandanda wa majini.Kafukufuku wamakono awonetsa kuti mankhwala ambiri a chemotherapeutic amatha kukwaniritsa zolinga zochiritsira poyambitsa apoptosis m'maselo a khansa.Kaya kukopa apoptosis yakhala imodzi mwazinthu zowunikira mankhwala oletsa khansa.

Melittin imatha kuletsa ntchito ya sPLA2 kuchokera kuzinthu zosiyanasiyana, ndipo kuchuluka kwa zoletsa za sPLA2 mu synovial fluid ya odwala a RA kumatha kufika 96%.Chifukwa chake, kugwiritsa ntchito melittin kumatha kuchepetsa kukula kwa RA.

Mlingo wocheperako wa melittin ukhoza kuchepetsa kwambiri kuchuluka kwa lysis kothandizira ma cell.Njira yotetezerayi ikhoza kukhala yokhudzana ndi melittin yomwe imalimbikitsa kuchuluka kwa Ca2 +, kulimbikitsa njira yotumizira ma sign a intracellular ndi kaphatikizidwe ka mapuloteni oteteza.Akuti kugwiritsa ntchito kuchuluka koyenera kwa melittin kuli ndi phindu pazachipatala pochiza RA ndi Chemicalbook.M'zaka zaposachedwa, kafukufuku wawonetsa kuti kuchuluka kosiyanasiyana kwa melittin kumatha kukhudza magwiridwe antchito a cell kudzera munjira zosiyanasiyana komanso kukhala ndi zotsatirapo zosiyanasiyana.Kugwiritsa ntchito moyenera melittin kumapereka chithandizo chatsopano cha matenda ena.