Nhanganyaya
Minoxidil, inozivikanwawo seyakareba kudzvinyirira idine, Minoxidil, molecular formula uye hama molecular uremu C9H15N5O = 209.25, yakachena kana yakachena crystalline poda, zvishoma soluble mumvura kana chloroform, zvishoma soluble mu ethanol, zvishoma soluble mu acetone, soluble mu acetic acid.Inogona kuita zvakananga pamadziro etsinga yeropa, dilate arterioles, kuderedza peripheral resistance, kuderedza BP, uye kuwedzera kurova kwemoyo uye kubuda kwemwoyo.Zvisinei, iyo antihypertensive effect inonyanya kukosha uye inogara kupfuura hydrazine.
Pharmacological effect
Minoxidil dilates ari arterioles zvakananga, nokudaro kuderedza BP, asi chaiyo nzira hazvizivikanwi.Ichi chigadzirwa hachinatsiri mavheni.Kuderedzwa kweperipheral vascular resistance kunotungamirira kukurumidza reflex heart rate uye kuwedzera kwemoyo.Basa reRenin rinowedzera mushure me hypotension, zvichiita kuti mvura uye kuchengetwa kwe sodium.Ichi chigadzirwa hachikanganise nevascular mota Chemicalbook reflex, saka orthostatic hypotension haina kuitika.Minoxidil inowanzoshandiswa uye inoshanda mushonga wekurapa kurasikirwa kwebvudzi, asi maitiro ayo emishonga uye masero anotarirwa haana kunyatsojeka.Mumakore achangopfuura, zvidzidzo zvakaratidza kuti Minoxidil inogona kukurudzira kukura kwebvudzi kuburikidza nenzira dzinotevera.
Mushonga wemukanwa unoshandiswa kuchipatara kuderedza BP
Minoxidil imhando yemushonga wemukanwa unoshandiswa kudzikisa BP mukiriniki, inozivikanwawo seChangbaridine, piperazine enediamine, hypotenidine uye Minlohemoidine.Iyo ndeye potassium chiteshi kuvhura mumiriri, iyo inogona kuzorodza zvakananga vascular yakatsetseka tsandanyama uye ine ine simba diki artery dilatation effect, inoderedza peripheral resistance, vascular dilatation uye blood pressure, asi haina mhedzisiro pamidziyo yevhoriyamu, saka inogona kukurudzira venous kudzoka.Panguva imwecheteyo, kubuda kwemoyo uye kurova kwemoyo kunogona kuwedzerwa nekuda kwekugadzirisa reflex uye positive frequency effect, asi haikonzeri postural hypotension.Clinically inoshandiswa pakurapa refractory hypertension uye renal hypertension.Inogonawo kushandiswa kune yakanyanya hypertension nekushaya mhinduro kune mamwe madhiragi antihypertensive, asi inoda kusanganiswa ne diuretics kudzivirira mvura uye sodium retention.Kana yakasanganiswa ne-β-blocking zvinodhaka, kushanda kwayo kunogona kuwedzera uye kukanganisa kwakashata kuderedzwa.Imwe mhedzisiro yekushandiswa kwenguva refu kweMinoxidil uye Chemicalbook ndeyekuti bvudzi remuviri rinogona kuwedzera zvishoma nekuenderera mberi nekushandisa mushonga, senge bvudzi remaoko.Asi kazhinji mukati memiganhu inogamuchirwa.Mhedzisiro yakashata yekutonga nemuromo inosanganisira kuwedzera uremu uye kuderera kwemakumbo edema kunokonzerwa nemvura uye sodium retention, palpitation uye arrhythmia inokonzerwa nereflex sympathetic nerve excitation, uye hirsuism.Kunyanya kuipa kwakashata kwekugadzirira kwepamusoro kwaive kutsamwa kweganda, erythema, pruritus uye mamwe maitiro edermatitis.Kunyange zvazvo kuwanda kwekutora mukugadzirwa kwepamusoro kwakanyanya kuduku, hazvigoni kutongerwa kuti inogona kuva nemigumisiro pamamiriro ezvinhu evarwere vane nhoroondo yehutano hwemwoyo.Varwere vane cerebrovascular chirwere, kutadza kwemoyo kusingakonzerwi neBP, coronary heart disease, angina pectoris, myocardial infarction, pericardial effusion, renal dysfunction nezvimwe zvirwere zvinofanirwa kushandiswa nemazvo, minoxidil allergy uye pheochromocytoma varwere vanofanirwa kupikisa.
Nguva yekutumira: Jan-06-2023