CAS: 38304-91-5 Minoxidil alostil lonolox

Mawu Oyamba

Minoxidil, yomwe imadziwikanso kuti idine yaitali, Minoxidil, molecular formula ndi kulemera kwa maselo C9H15N5O = 209.25, ndi ufa woyera kapena woyera wa crystalline, wosungunuka pang'ono m'madzi kapena chloroform, wosungunuka pang'ono mu Mowa, wosungunuka pang'ono mu acetone, sungunuka mu asidi asidi.Imatha kuchita mwachindunji pakhoma la mitsempha yamagazi, kukulitsa ma arterioles, kuchepetsa kukana zotumphukira, kuchepetsa kuthamanga kwa magazi, ndikuwonjezera kugunda kwa mtima ndi kutulutsa mtima.Komabe, mphamvu yake ya antihypertensive ndiyofunikira komanso yokhalitsa kuposa hydrazine.

Pharmacological zotsatira

Minoxidil dilates arterioles mwachindunji, potero kuchepetsa kuthamanga kwa magazi, koma limagwirira yeniyeni sichidziwika.Izi sizimakulitsa ma venu.Kuchepetsa kukana kwa mitsempha yotumphukira kumabweretsa kugunda kwamtima mwachangu komanso kuchuluka kwa mtima.Renin ntchito kumawonjezeka pambuyo hypotension, chifukwa madzi ndi sodium posungira.Izi sizimasokoneza vascular motor Chemicalbook reflex, kotero orthostatic hypotension sichitika.Minoxidil ndi mankhwala omwe amagwiritsidwa ntchito nthawi zambiri komanso othandiza pochiza tsitsi, koma zotsatira zake za pharmacological ndi maselo omwe akulimbana nawo sizodziwika bwino.M'zaka zaposachedwapa, kafukufuku wasonyeza kuti Minoxidil akhoza kulimbikitsa tsitsi kukula mwa njira zotsatirazi.

Mankhwala omwe amagwiritsidwa ntchito m'kamwa kuti achepetse kuthamanga kwa magazi

Minoxidil ndi mtundu wamankhwala amkamwa omwe amagwiritsidwa ntchito pochepetsa kuthamanga kwa magazi m'chipatala, omwe amadziwikanso kuti Changbaridine, piperazine enediamine, hypotenidine ndi Minlohemoidine.Ndi ya potaziyamu njira yotsegulira, yomwe imatha kumasuka mwachindunji minofu yosalala ya mitsempha ndipo imakhala ndi mphamvu yaing'ono yaing'ono ya dilatation, kuchepetsa kukana kwa zotumphukira, kuchepa kwa mitsempha ndi kuthamanga kwa magazi, koma ilibe mphamvu pamitsempha yamagazi, kotero imatha kulimbikitsa kubwerera kwa venous.Pa nthawi yomweyo, linanena bungwe mtima ndi kugunda kwa mtima akhoza ziwonjezeke chifukwa reflex regulation ndi zotsatira zabwino pafupipafupi, koma sayambitsa postural hypotension.Kuchipatala ntchito pa matenda a refractory matenda oopsa ndi aimpso matenda oopsa.Itha kugwiritsidwanso ntchito pa matenda oopsa kwambiri osayankhidwa bwino ndi mankhwala ena a antihypertensive, koma iyenera kuphatikizidwa ndi okodzetsa kuti mupewe madzi ndi sodium posungira.Mukaphatikizidwa ndi mankhwala a β-blocking, mphamvu yake imatha kukulitsidwa ndikuchepetsa zovuta zake.Chotsatira chimodzi chakugwiritsa ntchito kwa nthawi yayitali Minoxidil ndi Chemicalbook ndikuti tsitsi la thupi limatha kuchulukira pang'ono ndikupitiliza kugwiritsa ntchito mankhwalawa, monga tsitsi lamanja.Koma kawirikawiri mkati mwa malire ovomerezeka.Zotsatira zoyipa kwambiri za kayendetsedwe ka pakamwa zimaphatikizapo kunenepa komanso kutsika kwa edema ya miyendo chifukwa cha kusungidwa kwa madzi ndi sodium, palpitation ndi arrhythmia chifukwa cha reflex sympathetic nerve excitation, ndi hirsuism.Waukulu chokhwima zochita za apakhungu kukonzekera anali khungu kuyabwa, erythema, pruritus ndi zina dermatitis zimachitikira.Ngakhale kuchuluka kwa kuyamwa pakukonzekera pamutu kumakhala kochepa kwambiri, sikungatheke kuti kungakhale ndi zotsatira pa chikhalidwe cha odwala omwe ali ndi mbiri ya matenda a mtima.Odwala ndi cerebrovascular matenda, mtima kulephera osati chifukwa cha matenda oopsa, matenda a mtima, angina pectoris, myocardial infarction, pericardial effusion, aimpso kukanika ndi matenda ena ayenera kugwiritsidwa ntchito mosamala, minoxidil ziwengo ndi pheochromocytoma odwala ayenera contraindicated.