Taw qhia
Minoxidil, tseem hu ua ntev siab idine, Minoxidil, molecular mis thiab tus txheeb ze molecular hnyav C9H15N5O = 209.25, yog dawb los yog dawb crystalline hmoov, me ntsis soluble nyob rau hauv dej los yog chloroform, me ntsis soluble nyob rau hauv ethanol, me ntsis soluble nyob rau hauv acetone, soluble nyob rau hauv acetic acid.Nws tuaj yeem ua ncaj qha rau ntawm phab ntsa ntawm cov hlab ntsha, dilate arterioles, txo qis peripheral tsis kam, txo cov ntshav siab, thiab ua kom lub plawv dhia thiab lub plawv dhia.Txawm li cas los xij, nws cov nyhuv antihypertensive yog qhov tseem ceeb thiab ntev tshaj li hydrazine.
Pharmacological nyhuv
Minoxidil dilates arterioles ncaj qha, yog li txo cov ntshav siab, tab sis tsis paub meej mechanism.Cov khoom no tsis dilate venules.Kev txo qis peripheral vascular tsis kam ua rau lub plawv dhia nrawm thiab ua rau lub plawv dhia ntau ntxiv.Kev ua renin nce tom qab hypotension, ua rau dej thiab sodium tuav.Cov khoom no tsis cuam tshuam nrog vascular motor Chemicalbook reflex, yog li orthostatic hypotension tsis tshwm sim.Minoxidil yog ib qho tshuaj uas nquag siv thiab siv tau zoo rau kev kho cov plaub hau, tab sis nws cov teebmeem tshuaj thiab lub hom phiaj ntawm lub hlwb tsis meej heev.Nyob rau hauv xyoo tas los no, cov kev tshawb fawb tau pom tias Minoxidil tuaj yeem txhawb kev loj hlob ntawm cov plaub hau los ntawm cov hauv qab no.
Ib qho tshuaj hauv qhov ncauj siv kho mob kom txo cov ntshav siab
Minoxidil yog ib hom tshuaj siv los txo cov ntshav siab hauv tsev kho mob, tseem hu ua Changbaridine, piperazine ediamine, hypotenidine thiab Minlohemoidine.Nws belongs rau cov poov tshuaj channel qhib tus neeg sawv cev, uas tuaj yeem ncaj qha mus so vascular du nqaij thiab muaj zog me me hlab ntsha dilatation nyhuv, txo qis peripheral tsis kam, vascular dilatation thiab ntshav siab, tab sis tsis cuam tshuam rau cov hlab ntsha, yog li nws tuaj yeem txhawb nqa venous rov qab.Nyob rau tib lub sijhawm, cov txiaj ntsig ntawm lub plawv thiab lub plawv dhia tuaj yeem nce ntxiv vim yog kev tswj hwm reflex thiab muaj txiaj ntsig zoo, tab sis tsis ua rau lub cev hypotension.Clinically siv nyob rau hauv kev kho mob ntawm refractory hypertension thiab raum hypertension.Nws tseem tuaj yeem siv rau kev kub siab hnyav nrog cov lus teb tsis zoo rau lwm cov tshuaj tiv thaiv hypertensive, tab sis nws yuav tsum tau ua ke nrog diuretics kom tsis txhob muaj dej thiab sodium tuav.Thaum ua ke nrog cov tshuaj β-blocking, nws cov kev ua tau zoo tuaj yeem nce ntxiv thiab txo qis qhov tsis zoo.Ib qho kev mob tshwm sim ntawm kev siv mus sij hawm ntev ntawm Minoxidil thiab Chemicalbook yog tias lub cev plaub hau tuaj yeem nce me ntsis nrog kev siv tshuaj txuas ntxiv, xws li caj npab plaub hau.Tab sis feem ntau nyob rau hauv kev txwv.Cov teebmeem tseem ceeb ntawm kev tswj xyuas qhov ncauj muaj xws li qhov hnyav nce thiab qis qis qis los ntawm dej thiab sodium retention, palpitation thiab arrhythmia los ntawm reflex sympathetic paj excitation, thiab hirsuism.Lub ntsiab tsis zoo tshwm sim ntawm cov tshuaj pleev ib ce yog khaus tawv nqaij, erythema, pruritus thiab lwm yam dermatitis.Txawm hais tias qhov nqus ntawm cov tshuaj pleev ib ce muaj tsawg heev, nws tsis tuaj yeem txiav txim siab tias nws yuav cuam tshuam rau cov neeg mob uas muaj keeb kwm mob plawv.Cov neeg mob uas muaj kab mob cerebrovascular, lub plawv tsis ua haujlwm tsis yog los ntawm kev kub siab, kab mob plawv, angina pectoris, myocardial infarction, pericardial effusion, lub raum tsis ua haujlwm thiab lwm yam kab mob yuav tsum tau ua tib zoo siv, minoxidil allergy thiab pheochromocytoma cov neeg mob yuav tsum tau contraindicated.
Post lub sij hawm: Jan-06-2023