I-Clobetasol propionate ingelashwa i-psoriasis?Zonke izifo zesikhumba ezijwayelekile?

I-Clobetasol propionateingelashwa i-psoriasis.

Omqondofana:

17-propionate;cgp9555;Clobetasol 17-propionate solution,100ppm;Cloβsol propionate;21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-dionete; I-CLOBETASOL 17-PROPIONATE USP;[(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3 -oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate;Dermovate

Ukusetshenziswa:

I-Clobetasol Propionateiwuhlobo lukasawoti we-propionate we-clobetasol, i-topical synthetic corticosteroid ene-anti-inflammatory, anti-pruritic, ne-vasoconstrictive properties.I-Clobetasol propionate yenza umphumela wayo ngokubophezela kuma-cytoplasmic glucocorticoid receptors futhi kamuva isebenze i-glucocorticoid receptor mediated gene expression.Lokhu kubangela ukuhlanganiswa kwamaprotheni athile aphikisana nokuvuvukala, kuyilapho kuvimbela ukuhlanganiswa kwabaxhumanisi abathile bokuvuvukala.Ngokukhethekile, i-clobetasol propionate ibonakala yenza i-phospholipase A2 amaprotheni e-inhibitory, ngaleyo ndlela ilawula ukukhululwa kwe-archidonic acid eyandulela ukuvuvukala ku-membrane phospholipids nge-phospholipase A2.

I-Clobetasol propionate iyi-ester engu-17-O-propionate ye-clobetasol futhi itholakala ku-clobetasol ne-propionic acid.I-corticosteroid enamandla, isetshenziselwa ukwelapha izifo ezihlukahlukene zesikhumba, kuhlanganise ne-exzema ne-psoriasis.
I-Clobetasol propionate yanikezwa ilungelo lobunikazi ngo-1968 futhi yaqala ukusetshenziswa kwezokwelapha ngo-1978. Itholakala njengomuthi ojwayelekile.I-Clobetasol propionate isetshenziselwa ukwelapha izifo ezihlukahlukene zesikhumba ezihlanganisa i-eczema, i-herpes labialis, i-psoriasis, ne-lichen sclerosus.Ibuye isetshenziselwe ukwelapha izifo eziningana ezizimele, okuhlanganisa i-alopecia areata, i-lichen planus (i-auto immune nodules yesikhumba), kanye ne-mycosis fungoides (T-cell skin lymphoma).Isetshenziswa njengokwelashwa komugqa wokuqala kukho kokubili i-GVHD ebukhali futhi engapheli yesikhumba.I-Clobetasol propionate (Cormax, Temovate, Embeline, Olux) ingenye yama-ejenti anamandla atholakalayo njengamanje futhi ikhonjiswe ukwelashwa kwesikhashana kokuvuvukala. noma izinkinga ze-hyperplastic.Kuyi-synthetic fluorinated corticosteroid.Kungase kubangele impendulo eshesha kakhulu noma ende kunamanye ama-topical corticosteroids.Kutuswa ukuthi i-clobetasol ibe nesilinganiso esiphezulu esingu-60 g/ngeviki isikhathi esingekho ngaphezu kwezinsuku eziyi-14 ngaphandle kokuvaleka futhi akufanele isetshenziswe ezinganeni ezingaphansi kweminyaka engu-12.

Isixazululo se-betamethasone 21-methanesulfonate (4 g) ku-dimethylformamide (25 ml) siphathwe nge-lithium chloride (4 g) kanye nengxube eshisiwe kubhavu lomusi imizuzu engu-30.Ukuhlanjululwa ngamanzi kunikeze umkhiqizo ongahluziwe ophinde wahlanganiswa ukuze ukwazi ukukhokhela inhlanganisela yesihloko, i-MP 226°C.
I-Clobetasol imvamisa iguqulelwa ku-propionate njengendlela ewusizo ngokusabela nge-propionic anhydride.