Clobetasol propionate e ka phekoloa psoriasis?Mafu ohle a tloaelehileng a letlalo?

Clobetasol propionatee ka phekoloa psoriasis.

Mantsoe a tšoanang:

17-propionate;cgp9555;Clobetasol 17- propionate solution,100ppm;Cloβsol propionate;21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-dione; CLOBETASOL 17-PROPIONATE USP;[(8S,9R,10S,11S,13S,14S,16S,17R) -17-(2-chloroacetyl) -9-fluoro-11-hydroxy-10,13,16-trimethyl-3 -oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate;Dermovate

Tšebeliso:

Clobetasol PropionateKe mofuta oa letsoai oa propionate oa clobetasol, motsoako oa topical synthetic corticosteroid e nang le anti-inflammatory, anti-pruritic le vasoconstrictive properties.Clobetasol propionate e fana ka phello ea eona ka ho tlama li-receptor tsa cytoplasmic glucocorticoid ebe ka mor'a moo e kenya tšebetsong polelo ea liphatsa tsa lefutso tsa glucocorticoid receptor mediated.Sena se fella ka ho qaptjoa ha liprotheine tse itseng tse thibelang ho ruruha, ha li ntse li thibela ho kopana ha bakena-lipakeng ba itseng ba ho ruruha.Haholo-holo, clobetasol propionate e bonahala e kenya liprotheine tse thibelang phospholipase A2, kahoo e laola ho lokolloa ha arachidonic acid e bakoang ke membrane phospholipids ka phospholipase A2.

Clobetasol propionate ke 17-O-propionate ester ea clobetasol 'me e tsoa ho clobetasol le propionic acid.Ke corticosteroid e matla, e sebelisetsoang ho phekola mafu a fapaneng a letlalo, ho kenyelletsa exzema le psoriasis.
Clobetasol propionate e ne e na le tokelo ea molao ka 1968 'me e ile ea sebelisoa ho tsa bongaka ka 1978. E fumaneha e le meriana e tloaelehileng.Clobetasol propionate e sebelisoa bakeng sa kalafo ea mafu a fapaneng a letlalo ho kenyelletsa eczema, herpes labialis, psoriasis le lichen sclerosus.E boetse e sebelisoa ho alafa mafu a 'maloa a autoimmune, ho kenyelletsa le alopecia areata, lichen planus (li-nodule tsa letlalo la autoimmune), le mycosis fungoides (T-cell skin lymphoma).E sebelisoa e le phekolo ea pele bakeng sa GVHD e matla le e sa foleng ea letlalo.Clobetasol propionate (Cormax, Temovate, Embeline, Olux) ke e 'ngoe ea li-agent tse matla ka ho fetisisa tse teng hona joale' me e bontšoa bakeng sa phekolo ea nakoana ea ho ruruha. kapa mafu a hyperplastic.Ke corticosteroid e entsoeng ka fluorinated.E ka baka karabelo e potlakileng kapa e telele ho feta li-topical corticosteroids tse ling.Ho khothalletsoa hore clobetasol e be le tšebeliso e phahameng ea 60 g / beke bakeng sa matsatsi a fetang 14 ntle le ho koalloa le hore ha ea lokela ho sebelisoa ho bana ba ka tlase ho lilemo tse 12.

Tharollo ea betamethasone 21-methanesulfonate (4 g) ka dimethylformamide (25 ml) e ne e phekoloa ka lithium chloride (4 g) le motsoako o futhumetseng holim'a bateng ea mouoane ka metsotso e 30.Ho hlapolloa ka metsi ho ile ha fa sehlahisoa se tala se ileng sa nchafatsoa hape hore se lefelle motsoako oa sehlooho, MP 226 ° C.
Clobetasol hangata e fetoleloa ho propionate e le mokhoa o molemo ka ho arabela ka propionic anhydride.