Clobetasol propionatee mafai ona togafitia psoriasis.
upu uiga tutusa:
17-propionate;cgp9555;Clobetasol 17- propionate solution,100ppm;Cloβsol propionate;21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-propionate; CLOBETASOL 17-PROPIONATE USP;[(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3 -oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate;Dermovate
Fa'aoga:
Clobetasol Propionateo le masima propionate o le clobetasol, o se corticosteroid synthetic autu ma anti-inflammatory, anti-pruritic, ma vasoconstrictive meatotino.O le Clobetasol propionate e fa'aaogaina lona a'afiaga e ala i le fusifusia i le cytoplasmic glucocorticoid receptors ma mulimuli ane fa'agaoioia le glucocorticoid receptor mediated gene expression.O lenei mea e mafua ai le tuʻufaʻatasia o nisi o polotini anti-inflammatory, aʻo faʻalavelaveina le tuʻufaʻatasia o nisi faʻasalalauga faʻafefe.Aemaise lava, o le clobetasol propionate e foliga mai e faʻaosofia ai le phospholipase A2 inhibitory proteins, ma faʻapea ona pulea le tuʻuina atu o le inflammatory precursor arachidonic acid mai membrane phospholipids e le phospholipase A2.
Clobetasol propionate o le 17-O-propionate ester o clobetasol ma e maua mai i le clobetasol ma le propionic acid.O se corticosteroid malosi, e faʻaaogaina e togafitia ai faʻafitauli eseese o le paʻu, e aofia ai le exzema ma le psoriasis.
Clobetasol propionate na pateni i le 1968 ma na faʻaaogaina faʻafomaʻi i le 1978. O loʻo avanoa e avea o se vailaʻau lautele.Clobetasol propionate e faʻaaogaina mo togafitiga o faʻafitauli o le paʻu eseese e aofia ai le eczema, herpes labialis, psoriasis, ma le lichen sclerosus.E fa'aaogaina fo'i e togafitia ai le tele o fa'ama'i fa'ama'i, e aofia ai le alopecia areata, lichen planus (auto immune skin nodules), ma mycosis fungoides (T-cell skin lymphoma).E faʻaaogaina e avea ma togafitiga muamua mo le GVHD maʻi ma le tumau o le paʻu. Clobetasol propionate (Cormax, Temovate, Embeline, Olux) o se tasi o mea sili ona malosi o sui o loʻo avanoa nei ma faʻaalia mo togafitiga pupuu o le inflammatory. po'o fa'afitauli hyperplastic.O se corticosteroid fa'apipi'i fa'apipi'iina.E ono mafua ai se tali vave pe umi atu nai lo isi corticosteroids autu.E fautuaina le clobetasol e iai le maualuga o le faʻaaogaina o le 60 g/vaiaso mo le le sili atu i le 14 aso e aunoa ma se faʻalavelave ma e le tatau ona faʻaaogaina i tamaiti i lalo ole 12 tausaga.
O se vaifofo o le betamethasone 21-methanesulfonate (4 g) i le dimethylformamide (25 ml) sa togafitia i le lithium chloride (4 g) ma le faʻafefiloi faʻamafanafana i luga o le taele ausa mo le 30 minute.O le fa'avaivai i le vai na maua ai le oloa fa'atauva'a lea na toe fa'aili ina ia maua ai le fa'aigoa fa'aigoa, MP 226°C.
Clobetasol e masani ona liua i le propionate e pei o le aoga aoga e ala i le tali atu i le propionic anhydride.
Taimi meli: Ian-05-2023