Ana iya bi da Clobetasol propionate zuwa psoriasis?Duk cututtukan fata na yau da kullun?

Clobetasol propionateza a iya bi da psoriasis.

Makamantuwa:

17-propionate; cgp9555; Clobetasol 17-propionate bayani,100ppm;Cloβsol propionate;21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-propoonate; CLOBETASOL 17-PROPIONATE USP; -oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a] phenanthren-17-yl] propanoate;

Amfani:

Clobetasol Propionateshine nau'in gishiri na propionate na clobetasol, wani corticosteroid na roba na roba tare da anti-mai kumburi, anti-pruritic, da kayan vasoconstrictive.Clobetasol propionate yana aiwatar da tasirin sa ta hanyar ɗaure ga masu karɓar glucocorticoid na cytoplasmic kuma daga baya yana kunna maganganun maganganu na tsaka-tsakin mai karɓa na glucocorticoid.Wannan yana haifar da haɗakar wasu sunadaran anti-inflammatory, yayin da ke hana haɗin wasu masu shiga tsakani.Musamman, clobetasol propionate ya bayyana yana haifar da sunadaran inhibitory na phospholipase A2, ta haka ne ke sarrafa sakin mai kumburi precursor arachidonic acid daga membrane phospholipids ta phospholipase A2.

Clobetasol propionate shine 17-O-propionate ester na clobetasol kuma yana samuwa daga clobetasol da propionic acid.Corticosteroid mai ƙarfi, ana amfani dashi don magance cututtukan fata daban-daban, gami da exzema da psoriasis.
An ba da izinin Clobetasol propionate a cikin 1968 kuma ya zo cikin amfani da magani a cikin 1978. Ana samun shi azaman magani na gabaɗaya.Ana amfani da Clobetasol propionate don magance cututtukan fata daban-daban ciki har da eczema, herpes labialis, psoriasis, da lichen sclerosus.Ana kuma amfani da ita don magance cututtuka da yawa na autoimmune, ciki har da alopecia areata, lichen planus (auto rigakafi fata nodules), da mycosis fungoides (T-cell skin lymphoma).Ana amfani da shi azaman jiyya na farko don duka GVHD mai tsanani da na kullum na fata. ko rashin lafiyan hyperplastic.Corticosteroid na roba ne na roba.Yana iya haifar da amsa mai sauri ko tsayi fiye da sauran corticosteroids na sama.Ana ba da shawarar cewa clobetasol yana da matsakaicin aikace-aikacen 60 g/week na tsawon kwanaki 14 ba tare da ɓoyewa ba kuma kada a yi amfani da shi a cikin yara masu ƙasa da shekaru 12.

Maganin betamethasone 21-methanesulfonate (4 g) a cikin dimethylformamide (25 ml) an bi da shi tare da lithium chloride (4 g) da cakuda mai zafi akan wanka mai tururi na minti 30.Dilution da ruwa ya ba da ɗanyen samfurin wanda aka sake yin recrystallized don samun damar filin take, MP 226°C.
Clobetasol yawanci ana juyawa zuwa propionate azaman sifa mai amfani ta hanyar amsawa tare da propionic anhydride.