I-Nafarelin CAS: 76932-56-4 RS-94991-298 Nasanyl

I-Nafarelin, ethengiswa ngaphansi kwamagama okuhweba afana ne-Synarel, iyisidakamizwa se-gonadotropin ekhulula i-hormone (GnRH agonist) esetshenziselwa ukwelapha i-endometriosis kanye nokuthomba okungakafiki isikhathi eside.Ibuye isetshenziselwe ukwelapha i-uterine fibroids, ukulawula ukugqugquzelwa kwe-ovarian ngesikhathi sokukhulelwa kwe-in vitro (IVF), nanjengengxenye yokwelashwa kwama-hormone ocansini.Isidakamizwa sisetshenziswa njengesifutho sekhala kabili kuya kwezintathu ngosuku.

Imiphumela emibi ye-nafarelin ihlotshaniswa nokuncishwa kwe-hormone yocansi futhi ihlanganisa izimpawu zamazinga aphansi e-testosterone namazinga aphansi e-estrogen, njengokushisa okushisayo, ukungasebenzi kocansi, i-vaginal atrophy, kanye ne-osteoporosis.I-Nafarelin i-gonadotropin-releasing hormone agonist (GnRH agonist) esebenza ngokuvimbela ama-gonads ekukhiqizeni amahomoni ocansi.Inganciphisa amazinga amahomoni ocansi kubo bobabili ubulili ngamaphesenti angama-95.I-Nafarelin iyi-peptide eyi-analogue ye-GnRH.

I-Nafarelin yethulwa ukusetshenziswa kwezokwelapha ngo-1990. Isetshenziswa kabanzi emhlabeni wonke, kuhlanganise neNyakatho Melika, iYurophu, nezinye izingxenye zomhlaba.Isidakamizwa singesinye sezifaniso ezimbili kuphela ze-GnRH ezisetshenziswa ngokwezokwelapha ezitholakala njengesifutho samakhala, enye i-Bucherelin.

Ukusetshenziswa kwezokwelapha:
I-Nafarelin igunyazwe ukwelapha i-endometriosis kanye nokuthomba ngaphambi kwesikhathi.Ibuye isetshenziselwe ukwelapha i-uterine fibroids.Umuthi usetshenziselwa ukulawula ukugqugquzelwa kwe-ovarian ngesikhathi sokukhulelwa kwe-in vitro (IVF).I-Nafarelin isetshenziswa njengesivimbeli sokuthomba entsheni ye-transgender kanye nokucindezela amazinga e-testosterone kwabesifazane abashintsha ubulili.I-Nafarelin ingasetshenziswa futhi ukwelapha i-hypertrichosis kanye ne-polycystic ovary syndrome ngokunciphisa i-gonadotropin namazinga e-androgen.Isebenza ngempumelelo ekwelapheni i-benign prostatic hyperplasia