Nafarelin CAS: 76932-56-4 RS-94991-298 Nasanyl

I-Nafarelin, ethengiswa phantsi kwamagama orhwebo afana ne-Synarel, yi-gonadotropin ekhupha i-hormone agonist (i-GnRH agonist) ichiza elisetyenziselwa ukunyanga i-endometriosis kunye nokufikisa kwangaphambili.Ikwasetyenziselwa ukunyanga i-uterine fibroids, ukulawula ukuvuselela i-ovarian ngexesha le-in vitro fertilization (IVF), kwaye njengenxalenye yonyango lwe-hormone yesini.Ichiza lisetyenziswa njengesitshizi ngeempumlo kabini ukuya kathathu ngemini.

Imiphumo emibi ye-nafarelin idibene nokunciphisa i-hormone yesini kwaye ibandakanya iimpawu zamanqanaba aphantsi e-testosterone kunye namanqanaba aphantsi e-estrogen, njengokukhanya okutshisayo, ukungasebenzi ngokwesondo, i-vaginal atrophy, kunye ne-osteoporosis.I-Nafarelin yi-gonadotropin-releasing hormone agonist (GnRH agonist) esebenza ngokuthintela i-gonads ekuveliseni i-hormone yesini.Inokunciphisa amanqanaba e-hormone yesini kuzo zombini izini ngama-95 ekhulwini.I-Nafarelin yi-peptide eyi-analogue ye-GnRH.

I-Nafarelin yaziswa ukusetyenziswa kwezonyango kwi-1990. Isetyenziswa ngokubanzi kwihlabathi jikelele, kuquka uMntla Melika, iYurophu, kunye nezinye iindawo zehlabathi.Ichiza lelinye kuphela kwi-analogues ye-GnRH esetyenziswa kwezonyango ekhoyo njengesitshizi sempumlo, enye iyiBucherelin.

Ukusetyenziswa kwezonyango:
I-Nafarelin ivunyiwe ukunyanga i-endometriosis kunye nokufikisa kwangaphambili.Ikwasetyenziselwa ukunyanga i-uterine fibroids.Ichiza lisetyenziselwa ukulawula ukuvuselela i-ovarian ngexesha lokuchumisa kwe-in vitro (IVF).I-Nafarelin isetyenziswa njenge-blocker yokufikisa kulutsha lwe-transgender kunye nokucinezela amanqanaba e-testosterone kubasetyhini be-transgender.I-Nafarelin ingasetyenziselwa ukuphatha i-hypertrichosis kunye ne-polycystic ovary syndrome ngokunciphisa i-gonadotropin kunye namanqanaba e-androgen.Isebenza kakuhle ekuphatheni i-benign prostatic hyperplasia