I-GHRP-6 CAS: 87616-84-0 I-hormone yokukhula ekhulula i-peptide

incazelo emfushane:

INOMBOLO YE-CAS:87616-84-0

Igama:I-GHRP-6

Iphoyinti lokuncibilika :>160o C (Dec.)

Indawo yokubilisa:1407.0±65.0 °C(Kubikezelwe)

Ifomula yekhemikhali:C 46 H 56 N 12 O 6

ukuminyana :1.333±0.06 g/cm3(Kubikezelwe)

izinga lokushisa lokugcina.:−20°C

pka:13.42±0.46(Okubikezelwe)

ifomu:Okuqinile

I-Molar mass:873.032

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Ukusetshenziswa

I-peptide ekhipha i-hormone yokukhula i-6 (GHRP-6) (igama lekhodi yokuthuthukisa i-SKF-110679), eyaziwa nangokuthi i-hexapeptide ekhulula i-hormone, ingenye ye-analogues yokwenziwa ye-met-enkephalin ehlanganisa i-D-amino acid engeyona eyemvelo, yenzelwe bona. umsebenzi wokukhipha ama-hormone okukhula futhi abizwa ngokuthi ama-secretagogue ama-hormone okukhula.Abanawo umsebenzi we-opioid kodwa bangabakhuthazi abanamandla bokukhululwa kwe-hormone yokukhula.Lawa ma-secretagogue ahlukile ku-hormone yokukhula ekhipha i-hormone ngoba awahlanganyeli ngokulandelana futhi athola umsebenzi wawo ngokwenza kusebenze isamukeli esihluke ngokuphelele.Le receptor ekuqaleni yayibizwa ngokuthi i-hormone yokukhula i-secretagogue receptor, kodwa ngenxa yokutholwa okulandelayo, i-hormone ghrelin manje isithathwa njenge-endogenous ligand ye-receptor yemvelo, futhi isiqanjwe kabusha ngokuthi i-ghrelin receptor.Ngakho-ke, lawa ma-agonists e-GHSR enza njengama-synthetic ghrelin mimetics.

Kutholwe ukuthi lapho i-GHRP-6 ne-insulin kulawulwa kanyekanye, impendulo ye-GH ku-GHRP-6 iyanda.Nokho, ukusetshenziswa kwamacarbohydrate kanye/noma amafutha okudla, eduze kwefasitela lokuphatha lama-secretagogue e-GH kufiphaza kakhulu ukukhululwa kwe-GH.Ucwaningo lwakamuva kumagundane avamile lubonise umehluko omkhulu ekubunjweni komzimba, ukukhula kwemisipha, i-glucose metabolism, inkumbulo nokusebenza kwenhliziyo kumagundane aphethwe i-GHRP-6.Kusenemibuzo eminingi mayelana nale nhlanganisela entsha.