I-GHRP-6 CAS: 87616-84-0 Ukukhula kwehomoni ekhupha i-peptide

I-GHRP-6 CAS: 87616-84-0 Ihomoni yokukhula ikhupha i-peptide Umfanekiso ofakiweyo

inkcazelo emfutshane:

INOMBOLO YECASS:87616-84-0

Igama:GHRP-6

Indawo yokunyibilika :>160o C (Dec.)

Indawo yokubilisa :1407.0±65.0 °C(Kuxelwe kwangaphambili)

Ifomula yemichiza:C 46 H 56 N 12 O 6

Ubuninzi :1.333±0.06 g/cm3(Kuxelwe kwangaphambili)

ixesha lokugcina.:−20°C

pka:13.42±0.46(Kuxelwe kwangaphambili)

ifom:Iqinile

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Ukusetyenziswa

I-peptide ekhupha i-hormone yokukhula i-6 (GHRP-6) (igama lekhowudi yophuhliso SKF-110679), eyaziwa ngokuba yi-hexapeptide yokukhula kwehomoni, yenye yee-analogues ezininzi zokwenziwa ze-met-enkephalin ezibandakanya i-D-amino acids engekho ngokwemvelo, zaphuhliswa ngenxa yazo. umsebenzi wokukhulula ihomoni yokukhula kwaye zibizwa ngokuba zii-secretagogues zehomoni yokukhula.Abanamsebenzi we-opioid kodwa bangabakhuthazi abanamandla bokukhululwa kwehomoni yokukhula.Ezi secretagogues zahlukile kwi-hormone yokukhula ekhupha ihomoni kuba ababelana ngokulandelelana kwaye bafumana umsebenzi wabo ngokusebenza kwe-receptor eyahlukileyo ngokupheleleyo.Le receptor ekuqaleni yayibizwa ngokuba yi-hormone yokukhula secretagogue receptor, kodwa ngenxa yokufunyanwa okulandelayo, i-hormone ghrelin ngoku ithathwa njenge-receptor's endogenous ligand yendalo, kwaye iye yabizwa ngokuba yi-ghrelin receptor.Ke ngoko, ezi agonists zeGHSR zisebenza njengemimetics ye-ghrelin yokwenziwa.

Kuye kwafunyaniswa ukuba xa i-GHRP-6 kunye ne-insulin zilawulwa ngaxeshanye, impendulo ye-GH kwi-GHRP-6 yanda.Nangona kunjalo, ukusetyenziswa kwe-carbohydrates kunye / okanye amafutha okutya, malunga nefestile yokulawula ye-GH secretagogues kakhulu kuphazamisa ukukhutshwa kwe-GH.Uphononongo olutshanje kwiigundane eziqhelekileyo lubonise ukungafani okuphawulekayo ekubunjweni komzimba, ukukhula kwemisipha, i-glucose metabolism, imemori kunye nomsebenzi wenhliziyo kwiigundane ezilawulwa yi-GHRP-6.Kusekho imibuzo emininzi malunga nale khompawundi intsha.