I-Anti-Estrogen Ephumelelayo I-Exemestane / I-Aromasin Powder Yokuthola Imisipha CAS 107868-30-4
I-Exemestane(Aromasin)Imininingwane Yomkhiqizo
Igama lomkhiqizo: I-Exemestane
Synonym: Aromasin
I-CAS: 107868-30-4
MF: C20H24O2
MW: 296.4
mp: 155.13°C
izinga lokushisa lokulondoloza: Gcina ku -20°C
ukubukeka: impushana yekristalu emhlophe kuya kokuphuzi
Incazelo:
I-Aromasin isetshenziselwa ukulwa nomdlavuza webele futhi ikhulise i-testosterone emzimbeni.
I-Exemestane ivimba inqubo ye-aromatisation.Ngakho kwehlisa inani le-estrogen emzimbeni.Ekuqaleni komdlavuza webele, ukuthatha i-exemestane kungasiza ukunqanda ukubuya komdlavuza webele.Kumdlavuza webele osuthuthukile amangqamuzana omdlavuza angase akhule kancane kancane noma ayeke ukukhula ngokuphelele.
I-Exemestane iyi-aromatase inhibitor.Lokhu kusho ukuthi ivimba i-enzyme i-aromatase (etholakala emisipha yomzimba, esikhunjeni, emabeleni nasemafutheni), esetshenziselwa ukuguqula ama-androgens (amahomoni akhiqizwe izindlala ze-adrenal) abe yi-estrogen.Uma i-estrogen ingekho, izimila ezincike kule hormone ukuze zikhule zizoncipha
Ukusetshenziswa kwe-Exemestane(Aromasin).
1. Ingenye yezinhlanganisela ezinamandla kakhulu zokucindezela i-estrogen.
2. Ingenye yezinhlanganisela ezingcono kakhulu zokunciphisa umphumela we-aromatizing we-steroids.
3. Iyatholakala kubakhi bomzimba abathatha ama-anabolic steroids.
4. Isebenza ngokuvimbela i-enzyme aromatase, kamuva ivimbele ukukhiqizwa kwe-estrogen.
5. Futhi kuwuhlobo lwe-antineoplastic (hormonal) izinto zokusetshenziswa.
I-Exemestane(Aromasin)Izinhlelo zokusebenza
I-Aromasin isetshenziselwa ukulwa nomdlavuza webele futhi ikhulise i-testosterone emzimbeni.
I-Exemestane acetate ivimba inqubo ye-aromatisation.Ngakho kwehlisa inani le-estrogen emzimbeni.Ekuqaleni komdlavuza webele, ukuthatha i-exemestane acetate kungasiza ukumisa umdlavuza webele ukubuya.Kumdlavuza webele osuthuthukile amangqamuzana omdlavuza angase akhule kancane kancane noma ayeke ukukhula ngokuphelele.
Ama-aromatase inhibitors amaningi awawona ama-steroid kunoma yisiphi isimo noma isimo kodwa lapha kufanele senze okuhlukile.Qonda, abaningi abathenga i-Aromasin benza kanjalo ngoba ukusetshenziswa kwayo namanye ama-steroids ngokuvamile kungaba okubaluleke kakhulu mayelana nemiphumela emibi kodwa i-Aromasin ngokwayo iphethe izimfanelo ezithile ze-androgenic futhi.Noma kunjalo, ngenkathi sinemvelo ye-androgenic kungukunciphisa kwayo i-estrogen esikhathazeke ngayo kakhulu.
isizukulwane sesithathu i-aromatase inhibitors, esetshenziswa ekwelapheni umdlavuza webele we-metastatic futhi isetshenziswa njengosizo ekwelapheni umdlavuza webele wakuqala.
Izinhlobo eziningi zomdlavuza wamabele zikhuthazwa ukuba zikhule ngamahomoni ocansi wesifazane i-estrogen neprogesterone.Le midlavuza yebele ibizwa nge-hormone sensitive noma i-hormone receptor positive futhi ingelashwa ngemithi evimba imiphumela yala mahomoni.
Kwabesifazane asebenesikhathi sokunqamuka kokuya esikhathini, i-estrogen ikhiqizwa ngokuyinhloko ngokushintsha ama-androgens (amahomoni ocansi akhiqizwa izindlala ezikhiqiza ama-adrenal) abe ama-estrogen.Le nqubo ibizwa ngokuthi i-aromatisation futhi yenzeka ikakhulukazi ezicutshini ezinamafutha, imisipha kanye nesikhumba.Idinga i-enzyme ethile ebizwa ngokuthi i-aromatase.
I-Aromasin ivimba inqubo ye-aromasation.Ngakho kwehlisa inani le-estrogen emzimbeni.Ekuqaleni komdlavuza webele, ukuthatha i-Aromasin kungasiza ukumisa umdlavuza webele ukubuya.Kumdlavuza webele osuthuthukile amangqamuzana omdlavuza angase akhule kancane kancane noma ayeke ukukhula ngokuphelele.
