I-Anti-Estrogen Esebenzayo I-Exemestane / i-Aromasin Powder yokuFumana izihlunu CAS 107868-30-4
Exemestane(Aromasin)Iinkcukacha zeMveliso
Igama leMveliso: Exemestane
Izithethantonye: Aromasin
CAS: 107868-30-4
MF: C20H24O2
MW: 296.4
mp: 155.13°C
ubushushu bokugcina: Gcina kwi -20°C
inkangeleko: mhlophe ukuya kokukhanya komgubo wekristale otyheli
Inkcazo:
I-Aromasin isetyenziselwa ukulwa nomhlaza webele kunye nokunyusa i-testosterone emzimbeni.
I-Exemestane ivimba inkqubo ye-aromatization.Ngoko kunciphisa umthamo we-estrogen emzimbeni.Ekuqaleni komhlaza wamabele, ukuthatha i-exemestane kunokunceda ukunqanda umhlaza wamabele ukubuya.Kumhlaza webele okwinqanaba eliphezulu iiseli zomhlaza zinokukhula kancinci okanye ziyeke ukukhula ngokupheleleyo.
I-Exemestane yi-aromatase inhibitor.Oku kuthetha ukuba ithintela i-enzyme aromatase (efumaneka kwizihlunu zomzimba, ulusu, ibele kunye namafutha), esetyenziselwa ukuguqula i-androgens (iihomoni eziveliswa ngamadlala e-adrenal) zibe yi-estrogen.Xa i-estrogen ingekho, amathumba axhomekeke kule hormone ekukhuleni aya kuncipha
Usetyenziso lwe-Exemestane(Aromasin).
1. Yenye yezona zinto zinamandla zokucinezela i-estrogen.
2. Yenye yeekhompawundi ezingcono kakhulu zokunciphisa umphumo we-aromatizing we-steroids.
3. Iyafumaneka kubakhi bomzimba abathatha i-anabolic steroids.
4. Isebenza ngokuthintela i-enzyme aromatase, emva koko ivalela ukuveliswa kwe-estrogen.
5. Kwakhona luhlobo lwe-antineoplastic (hormonal) ekrwada.
Exemestane(Aromasin)Usetyenziso
I-Aromasin isetyenziselwa ukulwa nomhlaza webele kunye nokunyusa i-testosterone emzimbeni.
I-exemestane acetate ivimba inkqubo ye-aromatisation.Ngoko kunciphisa umthamo we-estrogen emzimbeni.Ekuqaleni komhlaza webele, ukuthatha i-exemestane acetate kunokunceda ukumisa umhlaza webele ubuye.Kumhlaza webele okwinqanaba eliphezulu iiseli zomhlaza zinokukhula kancinci okanye ziyeke ukukhula ngokupheleleyo.
Uninzi lwe-aromatase inhibitors alukho i-steroids kuyo nayiphi na imilo okanye ifom kodwa apha kufuneka senze okungafaniyo.Qonda, uninzi lwabo bathenga iAromasin benza njalo kuba ukusetyenziswa kwayo kunye nezinye isteroids kunokuba kubaluleke kakhulu malunga neziphumo ebezingalindelekanga kodwa iAromasin ngokwayo ineempawu ze androgenic ngokunjalo.Nangona kunjalo, ngelixa sinendalo ye-androgenic kukunciphisa kwayo i-estrogen sixhalabele kakhulu.
isizukulwana sesithathu i-aromatase inhibitors, esetyenziswa kunyango lomhlaza webele we-metastatic kwaye isetyenziswa njengoncedo kunyango lomhlaza wamabele kwangoko.
Uninzi lomhlaza wamabele luyakhuthazwa ukuba lukhule yihomoni yesini yabasetyhini i-estrogen kunye neprogesterone.Ezi zomhlaza zamabele zibizwa ngokuba yi-hormone sensitive okanye i-hormone receptor positive kwaye inokunyangwa ngamachiza athintela iziphumo zezi hormone.
Kwabasetyhini abaye bayeka ukuya exesheni, i-estrogen iveliswa ikakhulu ngokutshintsha ii-androgens (iihomoni zesini eziveliswa ngamadlala eadrenal) zibe zii-oestrogens.Le nkqubo ibizwa ngokuba yi-aromatization kwaye yenzeka ikakhulu kwizicubu ezinamafutha, izihlunu kunye nolusu.Ifuna i-enzyme ethile ebizwa ngokuba yi-aromatase.
I-Aromasin ivimba inkqubo yokuvumba.Ngoko kunciphisa umthamo we-estrogen emzimbeni.Ekuqaleni komhlaza wamabele, ukuthatha iAromasin kunokunceda ukunqanda umhlaza wamabele ukubuya.Kumhlaza webele okwinqanaba eliphezulu iiseli zomhlaza zinokukhula kancinci okanye ziyeke ukukhula ngokupheleleyo.
