Glucagon CAS: 16941-32-5 Glucagon(1-29) Human HCl GLUCAGON 1-37

Glucagon, inozivikanwawo se hyperglycemin uye glucagon, ihomoni yakatwasuka yepolypeptide inovanzwa ne α masero epancreatic islet, ine makumi maviri nepfumbamwe amino acids.Yayo molecular formula uye hukama huremu hwemamorekuru ndeye C153H225N43O49S = 3482.8.Iyi hormone yakagadzirwa munyika yangu.Ichena yakanaka crystalline poda pakamuri tembiricha, isinganhuhwi, isinganakidze.Isinganyunguriki mumvura uye yakawanda organic solvents, soluble mu dilute acid uye dilute lye.Kugadzirira kwakawanda kunogadzirwa nehydrochloride yayo, inonyungudika mumvura.Izvozvi zvave kuzivikanwa kuti glucagon inofanirwa kuchengetedza kuvimbika kwayo kwema molecular kuitira kuti iite basa rayo remuviri.Iyo hyperglycemic chimiro inogona kuenderana muvanhu nemhuka (tsuro, mombe, nguruve, makonzo, nezvimwewo), asi zvishoma zvakasiyana mushiri.Ihomoni yakakosha kuchengetedza shuga yeropa.Basa rayo guru nderekuita phosphorylase mumyocardium, kukurudzira glycogen kuora uye kuva nekatecholamin-semigumisiro.Nokudaro, ine simba rakasimba remwoyo pamwoyo, kuwedzera kurova kwemwoyo, myocardial contractility uye coronary blood flow.Cardioenhancement haina kuperekedzwa nekuwedzera kwemoyo kufara, asi inowedzera calcium ions mu cardiomyocytes uye inogona kumisa adenosine cyclase pachiropa cell membrane muChemicalbook, ichikurudzira kuumbwa kwecyclic adenosine phosphate mumasero.Glucagon inonzi inoshanda mune zvimwe zviitiko zvekutadza kwemoyo.Pamusoro pezvo, mazinga eplasma akawedzerawo kusvika kumadhigirii akasiyana muchirwere cheshuga, chirwere chechiropa, chirwere cheitsvo, glucagon tumor uye kusagadzikana.Glucagon ine mabasa mana emuviri ekusimudzira chiropa glycogenolysis, chiropa glycogenogenesis, lipolysis uye ketone kuumbwa kwemuviri.Inogona kukurudzira kutorwa kwemaamino acids mumasero echiropa, kukurumidza kuita deamination process yeamino acids muchiropa, kuderedza kuwanda kwemaamino acids muplasma, kuderedza protein synthesis uye kukurudzira chiropa glycogenogenesis.Mukuwedzera, inogonawo kumisa simba re lipase yemasero ekuchengetedza chiropa, kuwedzera kusunungurwa kwemahara emafuta acids, kukurumidza kuita lipoic acid oxidation maitiro emasero echiropa, uye kuwedzera kugadzirwa kwechiropa glyccoconeogenesis nemitumbi yeketone.Panguva imwecheteyo, glucagon inogona kurambidza kushushikana uye peristalsis yemudumbu, dumbu diki uye colon, kuderedza kushushikana kwegallbladder, inhibit pancreatic exocrine, uye inhibit kubatwa kwemvura nemunyu nemudumbu mucosa.Mahombe mahombe eglucagon anogonawo kuwedzera cAMP kusungwa mumasero emyocardial, kuwedzera kurova kwemoyo uye kuwedzera myocardial contractility.