Inhibitor GW0742 CAS 317318-84-6 budo cad
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Andarine (S-4) waa isku-dhafka arylpropionamide-ka soo jeeda [S-3- (4-acetylamino-phenoxy) -2-hydroxy-2-methyl-N- (4-nitro-3-trifluoromethyl-phenyl) -propionamide] marka hore waxaa sharaxay Yin et al.inuu noqdo modulator receptor androgen selective (SARM).Andarine (S-4) waxaa lagu muujiyay in vitro iyo in vivo daraasado si ay u noqdaan agonist anabolic wax ku ool ah, iyada oo aan lahayn waxyeellooyin soo noqnoqda oo inta badan la xidhiidha anabolic-androgenic steroids, oo la xidhiidha asaasiga ah ee xiriirka 5a-reductase si loo soo saaro DHT ee qanjirka 'prostate'.
Dhaqdhaqaaqa dawooyinka ee andarine waxay soo jeedinayaan kartida weyn ee andarine ee horumarinta SARM-yada caafimaad ee la heli karo, taas oo bixisa faa'iidooyin daaweyneed oo gaar ah oo ka badan dhiggooda steroidal iyo fursad xiiso leh oo lagu xakameynayo saameynta androgen ee unugyada kala duwan ee bartilmaameedka, sidaas awgeed yaraynta faragelinta caadiga ah. .Sidaa daraadeed, andarine waxay leedahay rajooyin tijaaboyin caafimaad oo horumarsan oo ujeedadoodu tahay in lagu daaweeyo jirrooyinka da'da la xiriira iyo in laga hortago calaamadaha cudurrada daran sida sarcopenia iyo kansarka cachexia.
Andarine waa daaweeyaha aan isteeroydhiska ahayn ee androgen receptor (AR) oo leh Ki of 4 nM.Andarine waxay muujisaa firfircoonida firfircoonida iyo firfircoonida anabolic waxayna keentaa kicinta qiyaasta-ku-tiirsanaanta koritaanka qanjirka 'prostate', xididdada seminal, siday u kala horreeyaan.Andarine waxay leedahay astaamo lid ku ah osteoporotic oo suurtagal ah.
Andarine (oo hore loogu yiqiin GTx-007; S-4; GTx007; S4) waa bioactive afka ah iyo xulashada non-steroid androgen receptor agonist (AR), gaar ahaan modulator androgen receptor modulator (SARM), kaas oo faa'iido u leh murqaha luminta iyo osteoporosis.Waxay ku hawlgelisaa AR oo leh Ki of 4 nM waxayna u tahay unug-xushay xubnaha anabolic.Andarine ayaa laga baarayaa daawaynta xaaladaha sida murqaha oo luma, lafo-jileeca iyo hypertrophy qanjirka 'benign prostate'.Qaabka xayawaanka ee qanjirka 'prostatic hypertrophy', andarine ayaa la muujiyay si loo yareeyo miisaanka qanjirka 'prostate' oo leh waxtarka la midka ah ee finasteride, laakiin iyada oo aan la soo saarin wax dhimis ah oo muruqa ah ama saameynaha anti-androgenic.
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Tilmaamaha
magac guud | SARM S4 | Magaca Ingiriisiga | Andarine |
Lambarka CAS | 401900-40-1 | miisaanka kelli | 441.358 |
cufnaanta | 1.5±0.1 g/cm3 | barta karkaraya | 698.7±55.0 °C at 760 mmHg |
caanaha molecular | C 19 H 18 F 3 N 3 O 6 | barta dhalaalaysa | 70-74ºC |
PSA | 133.48000 | Barta toosan | 376.4± 31.5 °C |
LogP | 4.01 | cadaadiska uumiga | 0.0±2.3 mmHg at 25°C |