Choroinic Gonadotrophin Human HCG CAS: 9002-61-3

Gonadotropin chorionic aadanaha (hCG) waa hoormoon glycoprotein ah oo ay soo daayaan unugyada endodermal mandheerta.Shaqadeeda ugu weyn waa in ay kiciso luteum corpus, taas oo u sahlaysa dheecaanka joogtada ah ee estrogen iyo progesterone, si kor loogu qaado samaynta ilmo-galeenka jajaban oo ka dhiga mandheerta koray oo qaan-gaar ah.Isla marka embriyaha la geliyo, unugyada blastoderm waxay bilaabaan inay soo saaraan hCG, markaa uurka waxaa lagu go'aamin karaa heerarka hCG ee dhiigga ama kaadida.

Waxay ka koobnayd 244 haraaga amino acid, oo leh miisaan kelli ah 36.7kDa iyo cabbir 7.5×3.5×3 nm.Waa heterodimer oo leh isla α-subunit sida hoormoonka luteining (LH), hoormoonka follicle-stimulating hormone (FSH) iyo thyrotropin (TSH), laakiin kala duwan β subunit.Qaybta α waxay ka koobnayd 92 haraaga amino acid, iyo β-subunit waxa ku jira 145 hadhaaga amino acid.

Isku-dhafka hCG ee haweenka si weyn ayaa loo kordhiyaa ka dib markii la rayraysiiyo, iyo joogitaanka hCG ee plasma iyo kaadida waa mid ka mid ah calaamadaha ugu horreeya ee uurka waxaana loo isticmaalaa baaritaanka uurka.

(1) Waxay leedahay shaqada FSH iyo LH si ay u ilaaliyaan muddada nolosha corpus luteum caadada waxayna ka dhigaan corpus luteum caadadu inay noqoto corpus luteum;

(2) Kor u udgoonka androgens galay estrogen, iyo kicin samaynta progesterone;

(3) Joojinta saameynta kicinta ee lectin dhirta ee lymphocytes, gonadotropin chorionic bini'aadamka ayaa lagu dhejin karaa dusha sare ee unugyada trophoblast, si looga fogaado weerarka unugyada trophoblast embriyaha ee lymphocytes hooyada;

(4) Shaqada LH, ka hor inta aan pituitary uurjiifku qarsoodiin LH, waxay kicisaa xiniinyaha uurjiifka si ay u qariso testosterone si kor loogu qaado kala duwanaanshaha galmada lab;Waxa kale oo ay kor u qaadi kartaa horumarinta gonadal, lab waxay kicin kartaa firfircoonida unugyada mesenchymal xiniinyaha, waxay kordhisaa dheecaanka hormoonka labka ah (testosterone).Waa muhiimad weyn oo loogu talagalay daaweynta bukaanada ragga ah ee leh cilladaha wadajirka ah ee pituitary, taas oo aan kor u qaadi karin horumarinta gonad iyo dheecaanka hormoonka labka ah, laakiin sidoo kale waxay kor u qaadaan horumarinta sifooyinka jinsiga labaad.

(5) Waxay ku xidhi kartaa qaboojiyaha TSH ee unugyada tayroodhka hooyada waxayna kicisaa dhaqdhaqaaqa tayroodhka.