Kordhi Koritaanka Muruqyada Farmamada Budada Darajada LGD-4033 CAS 1165910-22-4
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Isticmaalka
LGD-4033 waa mid aan afka isteeroydhiyaha ahayn, modulator receptor androgen-door ee dhalinyarada caafimaadka qaba.
Ligandrol (LGD-4033, VK-5211) waa nooc cusub oo isteeroydh ah oo xor ah iyo kan afka laga soo xushay nidaamiyaha daaweeyaha androgen oo leh xiriir sare (Kd wuxuu ku saabsan yahay 1 nM) iyo xulashada sare ee soo-dhoweynta androgen.
Noocyada xayawaanka, LGD-4033 waxay leedahay firfircoonida anabolic ee muruqa, xakameynta nuugista iyo dhaqdhaqaaqa anabolic ee lafaha, iyo xulashada muruqa ayaa ka sarreeya kan qanjidhada kiimikaad ee hore.Marka la eego feejignaanta, LGD-4033 waa badbaado oo si wanaagsan loo dulqaatay.Ciribtirkeeda nolosha nuska ah waa mid dheer, qiyaastii 24-36 saacadood, oo muujinaysa sifooyinka farmashiyaha tooska ah.
Tilmaamaha
| Magaca Alaabta: | LGD-4033 |
| CAS: | 1165910-22-4 |
| MF: | C14H12F6N2O |
| MW: | 338.25 |
| barta dhalaalaysa | 108 - 111°C |
| Barta karkarinta | 439.9±45.0 °C(La saadaaliyay) |
| cufnaanta | 1.45±0.1 g/cm3 (La saadaaliyay) |
| heerkulka kaydinta. | Hygroscopic, -20°C qaboojiyaha, Ku hoos jira jawi aan firfircoonayn |
| milmayn | Acetone (wax yar), Chloroform (wax yar, kuleyl), Methanol (wax yar) |
| pka | 12.06±0.20 (La saadaaliyay) |
| qaab | A adag crystalline |
| midab | Caddaan oo u socota Pale Beige |
| Xasilooni | Hygroscopic |
La mid ah:
1. 4-((R) -2-((R) -2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-trifluoroMethyl) benzonitrile (LGD-4033); LGD-4033
2. 4-[(2R) -2-[(1R) -2,2,2-Trifluoro-1-hydroxyethyl] -1-pyrrolidinyl]-2- (trifluoromethyl) benzonitrile
3. 4-((R)-2-((R)-2,2,2-Trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-trifluoroMethyl) benzonitrile
4. LIGANDROL
5. 4-[(2R) -2-[(1R) -2,2,2-trifluoro-1-hydroxyethyl] pyrrolidin-1-yl] -2- (trifluoromethyl) benzonitrile
6. lgd 4033 sarms budada lgd-4033 ligandrol
7. budada LGD-4033 LIGANDROL
8. CAS 1165910-22-4
