Umuntu Choroinic Gonadotrophin HCG CAS: 9002-61-3

Chorionic gonadotropin yumuntu (hCG) ni imisemburo ya glycoproteine ​​isohorwa na selile endodermal selile.Igikorwa cyacyo nyamukuru ni ugukangura corpus luteum, ifasha gusohora kwa estrogene na progesterone, kugirango biteze imbere gusama kwa nyababyeyi kandi bigatuma insimburangingo ikura kandi ikuze.Urusoro rukimara guterwa, selile ya blastoderm itangira gusohora hCG, bityo gutwita birashobora kugenwa nurwego rwa HCG mumaraso cyangwa inkari.

Ryari rigizwe n'ibisigazwa bya aside amine 244, bifite uburemere bwa molekuline 36.7kDa n'ubunini bwa 7.5 × 3.5 × 3 nm.Ni heterodimer ifite α subunit imwe na hormone ya luteinizing (LH), imisemburo itera imisemburo (FSH) na thyrotropine (TSH), ariko itandukanye β subunit.Sub subunit yarimo ibisigisigi bya aside amine 92, naho β subunit yarimo ibisigazwa bya aside amine 145.

Synthesis ya HCG mubagore yiyongera cyane nyuma yo gusama, kandi kuba hCG muri plasma ninkari nikimwe mubimenyetso byambere byo gutwita kandi bikoreshwa mugupima inda.

（1) Ifite imikorere ya FSH na LH kubungabunga ubuzima bwigihe cyimihango corpus luteum no gutuma imihango corpus luteum ihinduka gestational corpus luteum;

(2) Guteza imbere aromatisation ya andorogene muri estrogene, kandi igatera imiterere ya progesterone;

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.Irashobora kandi guteza imbere iterambere rya gonadal, igitsina gabo gishobora gutera imbaraga za selile testis mesenchymal selile, kongera imisemburo ya hormone yabagabo (testosterone).Ni ingirakamaro cyane mu kuvura abarwayi b'igitsina gabo bafite ubumuga bwa pitoito, budashobora guteza imbere iterambere rya gonad gusa no gusohora imisemburo ya hormone y'abagabo, ahubwo binateza imbere iterambere ry’ibiranga igitsina.

(5) Irashobora guhuza na TSH yakira ingirabuzimafatizo ya nyababyeyi kandi igatera imbaraga za tiroyide.