Ngwakọta ọgwụ na-arụ ọrụ Steroid Sarms CAS 595-33-5 Megestrol acetate
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Ozi bụ isi
Megestrol acetatebụ ụdị nnu acetate nke megestrol, ihe nrụpụta sịntetịt sitere na homonụ mmekọahụ nke nwanyị na-eme site n'okike progesterone nwere ikike mgbochi estrogen na antineoplastic.
A na-ejikarị ya agwọ ndị ọrịa nwere ọrịa kansa ara metastatic.A na-anabata ya nke ọma, belụsọ na ọ nwere ike ibute oke ibu na-adịghị mma.N'ikpeazụ, e gosiri na megestrol acetate na-emepụta uru dị arọ n'ọtụtụ ndị ọrịa cancer cachectic.
A na-ahụta mbelata nke ukwuu nke inserum IL-1a na b,IL-2,IL-6, na TNF-o na ndị ọrịa cancer na-eji megestrol acetate agwọ ọrịa nke nwere ike iburu n'usoro nke agụụ ka mma na uru ahụ. na mmetụta ahụ bụ, opekata mpe n'akụkụ, nke NPY na-akwado ya, ihe na-akpali agụụ agụụ nke etiti.
Ojiji
1. Megestrol acetate USP (Megace)A na-eji agwọ ọrịa Carcinoma nke ara ma ọ bụ endorometrium.
2. Megestrol acetate (MegaceSteroid progestational nke ọkara synthetic, bụ ihe na-akpali agụụ agụụ nke ama ama ugbu a.A na-ejibu ya na ndị ọrịa nwere ọrịa kansa na ndị nwere ọrịa immunodeficiency syndrome, ọ bụ naanị nyocha ole na ole tụlere uru ọgwụ a na ndị agadi anaghị eri nri.
Megestrol acetate bara uru ma ọ bụrụ na nnukwu anorexia bụ isi ngosipụta nke cachexia ma ọ bụrụ na a na-atụ anya nlanarị bụ izu ruo ọnwa.Egosiri Megace ka ọ na-abawanye agụụ, mana ọ bụghị ịlanarị.N'ime ndị ọrịa nwere nlanarị amụma dị mkpụmkpụ, usoro nkenke nke corticosteroids nwere ike ịba uru iji kpalite agụụ ma nwee mmetụta dị mma na ọgbụgbọ, mgbu, na asthenia.
Nkọwa izugbe
17-hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate(Megace), bụ progestin nke a na-eji eme ihe maka nchịkwa nchịkwa nke carcinoma ara na-emegharị ugboro ugboro, nke na-adịghị arụ ọrụ, ma ọ bụ metastatic endometrialor.E gosikwara Megestrol acetate maka mmụba agụụ na ndị ọrịa nwere AIDS. Ihe ndabere biochemical maka ojiji nke megestrol amabeghị.
Iji ụlọ ọgwụA na-emewanyewanye ọrụ progestin mgbe a na-ebute njikọ abụọ n'etiti ọnọdụ 6 na 7, dị ka a na-ahụ na megestrol acetate.A na-eji Megestrol eme ihe n'ụzọ bụ isi n'ịgwọ ọrịa ara na endometrial carcinomas yana na ụmụ nwanyị postmenopausal nwere carcinoma na-adabere na hormone dị elu.
Profaịlụ nchekwaCarcinogen a na-enyo enyo nwere nyocha carcinogenic na data teratogenic.Nsi site na eriri afọ.Mmetụta ịmụ nwa mmadụ bp ntinye na ụzọ ịkụnye: mmetụta na ovaries na tubes fallopian, mgbanwe okirikiri ịhụ nsọ, na mgbanwe ntụzịaka ọmụmụ nwanyị.Akọpụtara data mgbanwe.Mmetụta ọmụmụ nwale.Mgbe ọ na-ekpo ọkụ ka ire ere ọ na-ewepụta anwụrụ ọkụ na uzu ọkụ na-akpasu iwe.Otu ọgwụ nwere FDA eji agwọ endometriosis na ọrịa ara ara.A steroid.