I-NEUROPEPTIDE FF CAS:99566-27-5 PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE AMIDE PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2 NPFF NEUROPEPTIDE FF

incazelo emfushane:

INOMBOLO YE-CAS:99566-27-5

Igama:I-NEUROPEPTIDE FF

izinga lokushisa lokugcina.:−20°C

Ukunyibilika kwamanzi :Incibilika ibe ngu-0.50 mg/ml emanzini

Ifomula yekhemikhali:I-C54H76N14O10

ifomu:impushana

I-Molar mass:1081.27

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Ukusetshenziswa

I-NPFF Neuropeptide (FLFQPQRFa) iyi-neuropeptide ye-aminated aminated mammalian ekuqaleni eyayihlukanisiwe nobuchopho bezinkomo futhi ibonakala njenge-peptide elawula ubuhlungu nomsebenzi we-antiopioid ukuya ku-analgesia eyenziwe yi-morphine.

Kubantu, i-neuropeptide FF peptide ifakwe ikhodi yofuzo lwe-NPFF.Izakhi zofuzo ezimbili ezifaka ama-receptors amabili ahlukene (i-NPFF1 ne-NPFF2) kanye nama-precursors amabili (i-NPFFA ne-NPFFB) enziwe ezilwaneni ezincelisayo eziningana.

I-Neuropeptide FF (NPFF) kanye nama-peptide ahlobene ne-RFamide akhishwe izandulela ezimbili asebenzisana nama-subtypes amabili we-G-protein-coupled receptors, i-NPFF1 kanye ne-NPFF2 subtypes, enobudlelwane obuhle futhi ehilelekile emisebenzini ehlukahlukene yokuphila, njengokulawulwa kwenhliziyo nemithambo yegazi, ukulawula i-hormone, ukusebenza kwe-macrophage, i-thermohomeostasis, nokulawulwa kobuhlungu.

Ukwelashwa kwesandulela se-NPFFA endaweni eyisisekelo ye-proteolytic kufanele kuveze i-peptide equkethe i-NPFF, enama-amino acid amathathu engeziwe e-N-terminal ahluka ngokwezinhlobo zezinhlobo, kanye ne-peptide equkethe i-NPSF (SLAAPQRFa), ubude bayo buncike ohlotsheni.I-NPFFB ikhonjwe njengomanduleli we-peptide ehlobene ne-RFamide (RFRP, eyaziwa nangokuthi i-GnIH ye-gonadotropin-suppressing hormone), equkethe ama-peptide aqukethe i-LPLRFa nama-peptides abelana nge-C-terminal PQRFamide motif njenge-NPFF, njenge-NPVF (VPNLPQRFa) yomuntu.

I-NPFF kanye nezinhlelo ze-opioid ziboniswe ukuthi zisebenzisana emazingeni amaningi, kusukela ekuziphatheni kwezilwane kuya kuma-molecule e-receptor.I-Nociception iwumsebenzi womzimba ocwaningwe kakhulu walokhu kusebenzisana, kodwa umvuzo, ukunyakaza, ukudla kanye nokunyakaza kwamathumbu nakho kuyathinteka.Ama-opioid e-endogenous ayadingeka ezicini ze-analgesic zomjovo womgogodla we-NPFF, futhi ama-peptide e-NPFF angapheli ahilelekile enqubweni yokubekezelelana kwe-analgesic / hyperalgesia ebangelwa ukwelashwa kwe-opioid okungapheli.

I-NPFF iphinde ilawule inani kanye ne-metabolism yama-macrophages kuzicubu ze-adipose, okubalulekile empilweni yezicubu ze-adipose.