JWH18 Jwh18 5cl Sgt78 7A 7ad Adb S709 CAS 209414-07-3

I-JWH-018 (1-pentyl-3-(1-naphthoyl)indole, NA-PIMO noma i-AM-678) iyikhemikhali edambisa ubuhlungu emndenini we-naphthoyl indole, evezwa ku-CB 1 kanye ne-CB 2 cannabinoid receptors, Inezinye ukukhetha kwe-CB 2. Ikhiqiza imiphumela ezilwaneni ezifana ne-THC, i-cannabinoid etholakala ngokwemvelo ku-cannabis, okuholela ekusetshenzisweni kwayo emikhiqizweni ye-cannabis yokwenziwa, okuthi kwamanye amazwe idayiswe ngokusemthethweni ngokuthi "ingxube yephunga."

Njenge-agonist ephelele ye-CB 1 kanye ne-CB 2 cannabinoid receptors, le nhlanganisela ihlukaniswa njenge-analgesic.Imiphumela ye-analgesic ye-cannabinoid ligands mediated by CB1 receptors iboniswe kahle ekwelapheni ubuhlungu be-neuropathic, ubuhlungu bomdlavuza, kanye nesifo samathambo.

Lezi zinhlanganisela zisebenza ngokulingisa amahomoni e-endocannabinoid omzimba avela ngokwemvelo, njenge-2-AG ne-anandamide (AEA), asebenza ngokwebhayoloji futhi angaqinisa noma avimbele ukusayinda kwezinzwa.Ngenxa yokuthi kuncane okwaziwayo mayelana nezimbangela zezifunda zobuhlungu obungapheli, ucwaningo olwengeziwe kanye nentuthuko kufanele yenziwe ngaphambi kokuba amandla okwelapha anjalo ahlanganiswe nezinto eziphilayo angafezeka.