I-Hygromycin A CAS:6379-56-2 Homomycin
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Izakhiwo Zekhemikhali:
Impushana emhlophe.I-acidic ebuthakathaka.Incibilika ngokukhululekile emanzini nasetshwaleni.Ikhiqizwe yi-Streptomyces hygroscopicus.
Isebenzisa:
Hygromycin A, isibulala-magciwane esinganakiwe, sikhetha ngokukhetha amagciwane abangela isifo seLyme.Ikwazile ukwelapha isifo seLyme kumagundane ngaphandle kokuphazamisa i-microbiome.
Umuthi (i-broad-spectrum antibiotic).
Incazelo I-ChEBI: Umkhiqizo wemvelo otholakala ezinhlotsheni ze-Streptomyces.
I-SR 9009 iyi-agonist yokwenziwa ye-REV-ERB elawula ukuziphatha kwe-circadian kanye ne-metabolism;ingasetshenziswa ekwelapheni ukuphazamiseka kokulala nezifo ze-metabolic.Kuyinhlanganisela eholayo yekilasi elisha lezidakamizwa zomdlavuza ezihlotshaniswa newashi elijikelezayo lomzimba.
I-SR9009, eyaziwa nangokuthi i-Stenabolic, isidakamizwa socwaningo njenge-agonist ye-REV-ERB.
I-REV-ERB-α kanye ne-REV-ERB-β, ama-nuclear receptors amabili, anendima ebalulekile ekulawuleni ukuvezwa kwamaprotheni wewashi ashayela izigqi emsebenzini kanye ne-metabolism.
I-In vitro: Kokubili i-SR9009 kanye ne-analog SR9011 yayo ingakhuphula ngokuncika kumthamo umsebenzi wokucindezela oncike ku-REV-ERB ohlolwe kumaseli e-HEK293 aveza isizinda esibophayo se-chimaeric Gal4 DNA: REV-ERB isizinda esibopha i-ligand α noma i-β kanye ne-luciferase esabelayo ye-Gal4 .Ngaphezu kwalokho, i-SR9009 itholwe ikwazi ukucindezela isisho se-BMAL1 sesithunywa se-RNA kumaseli e-HepG2 ngendlela encike ku-REV-ERB-α/β.
Ku-vivo: Amagundane aphathwe ngomthamo owodwa we-SR9009, SR9011 noma imoto ngesikhathi se-circadian 6 (CT6 (6h ngemva kokukhanyisa izibani) ngemva kwezinsuku eziyi-12 ezimeni ze-D/D ezibonisa ukubonakaliswa okuphezulu kwe-Rev-erb-α. Imiphumela ibonise leyo moto. umjovo awubangeli ukuphazamiseka emsebenzini we-circadian locomotor. Ngokuphambene, ukuphathwa komthamo owodwa we-SR9009 noma SR9011 kuholele ekulahlekelweni komsebenzi we-locomotor phakathi nesigaba sobumnyama besihloko. Ngaphezu kwalokho, umsebenzi ojwayelekile ubuyisele umjikelezo we-circadian olandelayo, owawungaguquguquki. ngokuvunyelwa kwezidakamizwa esikhathini esingaphansi kwamahora angama-24.
