I-Organic Chemical Material eluhlaza Ifekthri Yekhwalithi Ephezulu Inikezela Ngokuqondile I-Troparil CAS 74163-84-1 Ukuze Ucwaninge

I-Troparil iyi-phenyltropane-based dopamine reuptake inhibitor etholakala ku-methylecgonidine.Kuyisidakamizwa esivuselelayo esisetshenziswa ocwaningweni lwesayensi.Uhlobo oluvame ukusetshenziswa kakhulu lwe-troparil usawoti we-tartrate, kodwa usawoti we-hydrochloride kanye ne-naphthalenedisulfonate nawo ayatholakala, kanye nesisekelo samahhala.
I-Troparil isetshenziswa ocwaningweni lwesayensi ku-dopamine reuptake transporter.Izinhlobo ze-3H-radiolabelled ze-troparil zisetshenziswe kubantu nasezilwaneni ukuze kumephu ukusatshalaliswa kwezithuthi ze-dopamine ebuchosheni.Ibuye isetshenziselwe ucwaningo lwezilwane.
I-Troparil inamandla izikhathi ezimbalwa kune-cocaine njenge-dopamine reuptake inhibitor, kodwa ayinawo amandla njenge-serotonin reuptake inhibitor, futhi inesikhathi esithatha izikhathi ezimbalwa ubude, njengoba indandatho ye-phenyl ixhunywe ngokuqondile neringi ye-tropane ngokusebenzisa okungeyona i- ibhondi ye-carbon-carbon-hydrolyzable.Ukuntuleka kokuxhunywa kwe-ester kususa isenzo sokubulala izinzwa endaweni emthini, ngakho-ke i-troparil iyisikhuthazi esimsulwa.Lolu shintsho emsebenzini futhi lwenza i-troparil ibe ne-cardiotoxic kancane kune-cocaine.