I-Agonist API GW501516 powder emhlophe
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Ukusetshenziswa
I-GW 501516 i-agonist ye-PPARδ enevelu ye-EC50 engu-1.1 nM.
I-GW501516 iboniswa njengama-agonists e-PPARα anamandla kakhulu futhi akhethayo aziwa nge-EC 50 ye-1. I-1 nM ngokumelene ne-PPARα kanye nokukhetha okuphindwe ka-1000 ngaphezu kwezinye izinhlobo ezincane zabantu, i-PPARα kanye -γ.I-GW501516 inemiphumela yokulwa nokuvuvukala kumaseli e-proximal tubular (mProx) enziwe ngamagundane.I-GW501516 ivimbela ukukhuphuka okubangelwa i-palmitate- kanye ne-TNFα kusisho se-MCP-1 mRNA ngendlela encike kumthamo.
I-GW501516 ibangela ukwakheka kwamathambo okukhubazekile, okuholela ekwehleni kwe-BMD kanye nokuwohloka kwezakhiwo zamathambo kumagundane e-OVX.I-GW501516 inciphisa ukuvuvukala kwe-interstitial kanye nokulimala kweseli ye-tubular eseduze kumodeli yegundane egcwele amaprotheni.Ukwelashwa kwe-GW501516 kuthuthukisa ukukhuthazela okugijima kanye nengxenye ye-succinate dehydrogenase (SDH) -imisipha emihle yemisipha kuwo womabili amagundane aqeqeshiwe nangaqeqeshiwe.
Imininingwane
| Igama elivamile | I-GW-501516 | Igama lesiNgisi | GW501516 |
| Inombolo ye-CAS | 317318-70-0 | isisindo samangqamuzana | 453.498 |
| ukuminyana | 1.4±0.1 g/cm3 | indawo abilayo | 584.5±60.0 °C ku-760 mmHg |
| ifomula yamangqamuzana | I-C21H18F3NO3S2 | indawo yokuncibilika | 134-136°C |
| I-PSA | 112.96000 | iphoyinti elikhanyayo | 307.3±32.9 °C |