Umkhiqizo we-Prostaglandins Chemical 99% purity API Material Lumigan Bimatoprost CAS 155206-00-1 yokwelapha iso
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Ukusetshenziswa
I-Bimatoprost iyisidakamizwa se-prostaglandin esasetshenziswa okokuqala ukwelapha izifo zamehlo njenge-glaucoma.Igama lomuthi nguLumigan.Kodwa-ke, ngesikhathi sokwelashwa, isiguli sathola ngokungalindelekile ukuthi ububanzi, ubude nobuningi be-eyelashes yakhe kuye kwanda kakhulu.Ngemuva kwalokho, i-bimatoprost yasetshenziswa ezivivinyweni zomtholampilo zobuhle be-eyelash.Umthelela wayo omkhulu ekukhohliseni nasekuqinisweni kwe-eyelashes uholele ngokuqondile ekwethulweni kweLattise yinkampani yokukhiqiza kaLumegen, i-Allergan.Umuthi wethulwa ngoDisemba 2008. Wagunyazwa yi-US FDA, usuphenduke umkhiqizo ochwepheshe wokumnyama nokujiya izinkophe.
NgoJulayi 2006, i-bimatoprost-timolol maleate amaconsi ehlo ayinhlanganisela athuthukiswe yi-United States Allergan Co., Ltd. yagunyazwa iziphathimandla zezemithi ze-EU ukuze kuncishiswe impendulo ekuvimbeni okukodwa kwe-β-receptor noma i-prostaglandin.Ingcindezi ye-intraocular noma i-ocular hypertension ezigulini ezine-glaucoma evulekile-angle ezingaphenduli ngokwanele ekwelashweni kwe-analog.Amaconsi eso ayinhlanganisela aqukethe u-0.0Chemicalbook3% bimatoprost kanye no-0.5% we-timolol maleate, kanye ngosuku, anganikeza umphumela wokulawula ukucindezela kwe-intraocular osebenza kahle kakhulu ngokomtholampilo, futhi umphumela ungcono kunalowo we-bimatoprost iyodwa.I-Matoprost noma i-timolol maleate.Izivivinyo zemitholampilo ziqinisekisile ukuthi umuthi unokubekezeleleka okuhle kakhulu, okubandakanya ukwehla okungama-40% kwezehlakalo ze-ocular hyperemia uma kuqhathaniswa ne-bimatoprost iyodwa.
Ukwelashwa kwe-glaucoma, ingasetshenziswa futhi ekukhuleni kwe-eyelashe liquid, ukugxila ku-0.03%
Imininingwane
| Igama Lomkhiqizo | I-Bimatoprost |
| I-CAS | 155206-00-1 |
| Ukuminyana | 1.1 ± 0.1 g/cm3 |
| Iphuzu elibilayo | 629.8 ± 55.0 ° C AT 760 mmHg |
| Iphoyinti lokuncibilika | 66-68 ° C |
| Amangqamuzana | I-C25H37NO4 |
| Isisindo samangqamuzana | 415.566 |
| Iphoyinti le-Flash | 334.7 ± 31.5 ° C |
| Ikhwalithi Enembile | 415.272247 |
| I-PSA | 89.79000 |
| Ilogi | 1.98 |
| Ukubukeka | I-Crystal Solid |
| Umfutho we-steam | 0.0 ± 1.9 mmHg AT 25 ° C |
| Inkomba ye-refractive | 1.591 |
| Izimo zokugcina | 20 ° C |
Olunye ucwaningo lwe-Bimatoprost CAS 155206-00-1:
I-Olaparib ibisebenza kahle ngokumelene ne-Brca1;p53 amathumba ebele (50mg/kg umjovo we-intraperitoneal ngosuku), kodwa ayizange ibe nomthelela ku-HR-eshoda nge-Ecad;p53 izimila zamabele.I-Olaparib yayingenabo ubuthi obukhawulela umthamo kumagundane aphethe isimila.I-Olaparib isetshenziselwe ukwelapha izimila ngokuguqulwa kwe-BRCA, njengomdlavuza we-ovarian, umdlavuza webele, nomdlavuza wendlala yesinye.Ngaphezu kwalokho, i-Olaparib ivimbele amaseli e-tumor ashoda nge-ATM ngokukhetha, iphakamisa ukuthi i-Olaparib ingasetshenziswa njenge-ejenti engase ibe khona ekwelapheni izimila ze-lymphoid eziguqulwe i-ATM.
I-Olaparib iyi-PARP inhibitor ephinda isebenze ngokumelene nokuguqulwa kwe-BRCA1 noma kwe-BRCA2.I-Olaparib inomphumela omncane ku-tanky (polymer) enzyme-1, futhi inani le-IC50 likhulu kunalokho.I-Olaparib ekuhlanganiseni okungu-30-100nM isebenza kumaseli e-SW620 ukuze yenze i-PARP-1 isebenze.Imigqa yeseli entula i-BRCA1 (MDA-MB-463[1] kanye ne-HCC1937) izwela kakhulu ku-Olaparib uma iqhathaniswa ne-BRCA1- kanye nemigqa yamaseli anele ye-BRCA2 (Hs578T,MDA-MB-23,T47D) I-Olaparib ivimbela i-PARP futhi ivimbela isisekelo sokulungisa , okuholela ekuzweleni okunamandla kwamaseli e-KB2P ku-Olaparib.Umphumela uwukuguqulwa kokunqamuka komucu owodwa kube ukunqamuka kwemicu ekabili ngesikhathi sokuphindaphinda kwe-DNA, ngaleyo ndlela kusebenze indlela yokuhlanganisa encike ku-BRCA2.
I-Bimatoprost iyi-synthetic prostamide F2α derivative, engakwazi ngokukhetha ukulingisa umphumela we-prostamine ekhiqizwa emzimbeni, ikhuphule izinga lokukhiqizwa kwamahlaya ane-aqueous, inciphise ukumelana nokuphuma kwe-aqueous humor, futhi ikhulise isiteshi senethiwekhi ye-trabecular kanye ne-uveal sclera. kube yisidakamizwa sendawo se-anti-glaucoma esinomthelela onamandla kakhulu ekwehliseni ingcindezi ye-intraocular.Ilungele ukwelashwa kwe-open-angle glaucoma (POAG) noma amehlo aphezulu angasebenzi nezinye izidakamizwa zokwehlisa umfutho we-intraocular.Iziguli ezine-Hypertension (OHT).
Kuphawuliwe:
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