Ọja kemikali Bromazolam CAS 71368-80-4
Alaye ipilẹ
Ilana molikula: C17H13BrN4
- Ojuami yo: 272.0-275 ℃
- Ojutu farabale: 519.8± 60.0 °C (Asọtẹlẹ)
- iwuwo: 1.54± 0.1 g/cm3 (20 ºC 760 Torr)
- pka: 2.37± 0.40 (sọtẹlẹ)
- Ilana molikula: C17H13BrN4
- Iwọn Molikula: 353.21600
- Gangan Ibi: 352.03200
- PSA: 43.07000
- Wọle: 3.12480
Lilo
Bromazolam jẹ ipin bi aramada benzodiazepine eyiti a ti kọkọ ṣepọ ni ọdun 1976, ṣugbọn ko ṣe tita rara.Lẹhinna o ti ta bi oogun onise, ni akọkọ ti idanimọ nipasẹ EMCDDA ni Sweden ni ọdun 2016. O jẹ bromo dipo analogue chloro ti alprazolam, ati pe o ni iru sedative ati awọn ipa anxiolytic.Bromazolam jọra ni igbekalẹ si awọn benzodiazepines ibile, pẹlu alprazolam (fidipo chlorine pẹlu bromine) ati bromazepam (afikun oruka triazole).Alprazolam ati bromazepam jẹ awọn nkan Iṣeto IV ni Amẹrika;bromazolam ko ṣe eto ni gbangba.
8-Bromo-1-methyl-6-phenyl-4H-s-triazolo [4,3-a] [1,4] benzodiazepine ni a lo lati ṣe iwadi iṣẹ aibalẹ, antidepressant ati psychotropics fun eto aifọkanbalẹ aarin.
Ọna Igbaradi
Wọn ṣe itọju pẹlu pHLS9 (2 mg protein / mL), 25 μg/mL Alamethicin (UGT reaction mix B), 90 mM phosphate buffer (pH 7.4), 2.5 mM mg 2+, 2.5 mM isocitrate, ati 0.6 mM ni 37 ° C NADP +, 0.9 U/ml isocitrate dehydrogenase, 100 U/mL superoxide dismutase ati 0.1 mM acetyl-CoA.Lẹhinna, 2.5 mM UDP-glucuronic acid (UGT reaction mix solution A), 40 μM PAPS, 1.2 mM SAM, 1 mM dithiothreitol, 10 mM glutathione, ati 50 μM clobromazolam tabi Bromazolam ni a fi kun.
Awọn ipo Idahun:50 μM Bromazolam fun 360min ni 37°C
Awọn ohun elo:Bromazolam metabolites jẹmọni pHLS9 abeabo.