I-Trenbolone Cyclohexylmethylcarbonate CAS: 23454-33-3 11-trien-3-one carbonate cyclohexylMethylcarbonate (8CI)

Intshayelelo emfutshane:
I-Trenbolone (TRE) isetyenziswa ngokubanzi i-steroid protein assimilation hormone.Yinto ephuma kwi-chemosynthetic efana ne-testosterone yehomoni yomntu kwisakhiwo kunye nomsebenzi.Iyakwazi ukukhuthaza iprotheni synthesis, ukwandisa ukutya, ukwandisa imisipha, ukukhuthaza i-calcium kunye ne-phosphorus kwizicubu zethambo, kwaye ingasetyenziselwa iklinikhi ukunyanga ukunqongophala kwesondlo esinzima kunye ne-osteoporosis, kodwa kwakhona luhlobo olusetyenziswa rhoqo lwezemidlalo ezikhuthazayo.Iqela le-bolone i-cyclohexyl methyl carbonate ingasetyenziselwa njenge-synthetic intermediate yeqela leBolone.
Ukulungiselela:
Iqela le-bromcyclohexyl methyl carbonate lilungiswe ngolu hlobo lulandelayo:
I-3G17/3-hydroxy-estradiol-4,9, i-11-triene-3-enye yachithwa kwi-pyridine kwi-15℃ kunye ne-0℃ phantsi kwe-agitation kunye ne-nitrogen emoyeni.Gcina iqondo lobushushu liphakathi kwe-0 kunye ne-10 ngokukaCelsius.Yongeza kancinane i-50ml i-hexahydrobenzyl chloride Chemicalbook formate, emva koko ufudumeze wonke umxube kwiqondo lobushushu le-ambient, ugxobhoze iiyure ezi-2, emva koko uphole ukuya ku-0 ° C. Yongeza i-triethylamine kwaye uvuthulule imizuzu engama-30 ukunyusa ubushushu kwi-ambient kwaye ugalele umxube wokuphendula amanzi / umxube womkhenkce.Ikhutshwe nge-methylene chloride, kwaye isigaba se-organic sihlanjwe ngamanzi ukuba singathathi hlangothi, somiswe nge-sodium sulfate, kwaye siphephe phantsi kwe-vacuum de somile.Intsalela yahlulwe ngechromatography kwijeli yesilica, yahluzwa ngomxube we-4:1 we-benzene/ethyl acetate, yaze yaphinda yahluzwa kumxube we-isopropyl ether/hexane.I-Chromatography yenziwe kwakhona kwijeli ye-silica, ixutywe nomxube we-benzene/ethyl acetate, kwaye ekugqibeleni yaphinda yaphinda yahluzwa kwi-cyclohexane kunye ne-petroleum ether ukufumana i-1.60g yeqela le-bromcyclohexyl methyl carbonate.Imveliso ibonakala njengeprism enyibilikayo kwi-ethanol, i-ether, ibenzene, i-acetone, kunye ne-chloroform, kodwa ayinyibiliki emanzini, i-asidi edibeneyo, kunye nezinyibiliko ze-lye.