NEUROPEPTIDE FF CAS:99566-27-5 PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE AMIDE PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2 NPFF NEUROPEPTIDE FF

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INOMBOLO YECASS:99566-27-5

Igama:NEUROPEPTIDE FF

ixesha lokugcina.:−20°C

Ukunyibilika kwamanzi :I-Soluble ukuya kwi-0.50 mg / ml emanzini

Ifomula yemichiza:I-C54H76N14O10

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Ukusetyenziswa

I-NPFF Neuropeptide (FLFQPQRFa) yi-mammalian aminated neuropeptide ekuqaleni eyayikhelwe yodwa kwingqondo yenkomo kwaye ibonakaliswe njenge-peptide elawula iintlungu kunye nomsebenzi we-antiopioid ukuya kwi-morphine-induced analgesia.

Ebantwini, i-neuropeptide FF peptide ifakwe kwi-NPFF gene.Iijini ezimbini ezifakela ii-receptors ezimbini ezahlukeneyo (NPFF1 kunye ne-NPFF2) kunye nezandulela ezimbini (i-NPFFA kunye ne-NPFFB) ziye zenziwa kwizilwanyana ezininzi ezanyisayo.

I-Neuropeptide FF (NPFF) kunye neepeptide ezinxulumene ne-RFamide ezikhutshwe ngabaphambili ababini basebenzisana kunye ne-subtypes ezimbini ze-G-protein-coupled receptors, i-NPFF1 kunye ne-NPFF2 subtypes, kunye nobudlelwane obuhle kwaye babandakanyeka kwimisebenzi eyahlukeneyo ye-physiological, njengokulawulwa kwe-cardiovascular regulation, ulawulo hormone, ukusebenza macrophage, thermohomeostasis, kunye nommiselo intlungu.

Unyango lwe-NPFFA ye-precursor kwindawo esisiseko yeproteolytic kufuneka ivelise i-peptide equlethe i-NPFF, kunye ne-N-terminal amino acids ezintathu ezongezelelweyo ezishiya iintlobo ngeentlobo, kunye ne-peptide equlethe i-NPSF (SLAAPQRFa), ubude bayo buxhomekeke kwiintlobo.I-NPFFB ichongiwe njenge-precursor ye-peptide ehlobene ne-RFamide (RFRP, eyaziwa ngokuba yi-GnIH ye-gonadotropin-suppressing hormone), equkethe i-peptides equkethe i-LPLRFa kunye ne-peptides ekwabelana nge-C-terminal ye-PQRFamide motif njenge-NPFF, njenge-NPVF (VPNLPQRFa) yomntu.

I-NPFF kunye neenkqubo ze-opioid ziye zaboniswa ukuba zisebenzisana kumanqanaba amaninzi, ukusuka kwindlela yokuziphatha kwezilwanyana ukuya kwii-molecule ze-receptor.I-Nociception ngowona msebenzi we-physiological owenziwe kakhulu kule ntsebenziswano, kodwa umvuzo, ukunyakaza, ukutya kunye nokunyakaza kwamathumbu kuyachaphazeleka.I-opioids engapheliyo iyadingeka kwiipropati ze-analgesic ze-spinal injection ye-NPFF, kwaye i-peptide ye-NPFF engapheliyo ibandakanyeka kwinkqubo yokunyamezela i-analgesic / hyperalgesia eyenziwa yi-opioid therapy engapheliyo.

I-NPFF ikwalawula inani kunye ne-metabolism ye-macrophages kwi-adipose tissue, eyimfuneko kwimpilo ye-adipose tissue.