JWH18 Jwh18 5cl Sgt78 7A 7ad Adb S709 CAS 209414-07-3

I-JWH-018 (1-pentyl-3- (1-naphthoyl) indole, i-NA-PIMO okanye i-AM-678) yikhemikhali ye-analgesic kwintsapho ye-naphthoyl indole, echazwe kwi-CB 1 kunye ne-CB 2 i-cannabinoid receptors, Inento ethile. i-selectivity ye-CB 2. Ivelisa iziphumo kwizilwanyana ezifana ne-THC, i-cannabinoid efunyenwe ngokwemvelo kwi-cannabis, ekhokelela ekusebenziseni kwayo kwimveliso ye-cannabis yokwenziwa, kwamanye amazwe athengiswa ngokusemthethweni "njenge-fragrance blends."

Njenge-agonist epheleleyo ye-CB 1 kunye ne-CB 2 i-cannabinoid receptors, le ngqungquthela ihlelwa njenge-analgesic.Imiphumo ye-analgesic ye-cannabinoid ligands ephakathi kwe-receptors ye-CB1 ibonakaliswe kakuhle kunyango lwentlungu ye-neuropathic, intlungu yomhlaza kunye nesifo samathambo.

Ezi khompawundi zisebenza ngokulinganisa iihomoni ze-endocannabinoid ezenzeka ngokwemvelo emzimbeni, ezifana ne-2-AG kunye ne-anandamide (AEA), ezisebenza ngokwebhayoloji kwaye zinokuqinisa okanye zithintele ukubonakaliswa kwemithambo-luvo.Ngenxa yokuba kuncinci okwaziwayo malunga nezizathu zentlungu engapheliyo, uphando olongezelelweyo kunye nophuhliso kufuneka lwenziwe ngaphambi kokuba amandla onyango anjalo ahlanganiswe kwizinto eziphilayo.