I-Hygromycin A CAS: 6379-56-2 Homomycin

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Iinkcazelo ngeMichiza:
Umgubo omhlophe.I-asidi ebuthathaka.Inyibilika ngokukhululekileyo emanzini nasetywaleni.Iveliswe nguStreptomyces hygroscopicus.
Usebenzisa:
Hygromycin A, iyeza lokubulala iintsholongwane elingakhathalelwanga, lizibulala ngokukhethekileyo iintsholongwane ezibangela isifo seLyme.Yakwazi ukunyanga isifo seLyme kwiimpuku ngaphandle kokuphazamisa i-microbiome.
Amayeza (i-antibiotic ebanzi).
Inkcazo ye-ChEBI: Imveliso yendalo efumaneka kwiintlobo ze-Streptomyces.

I-SR 9009 yi-agonist yokwenziwa kwe-REV-ERB elawula ukuziphatha kwe-circadian kunye ne-metabolism;inosetyenziso olunokubakho kunyango lweengxaki zokulala kunye nezifo ze-metabolic.Yikhompawundi ekhokelayo yodidi olutsha lwamachiza omhlaza anxulumene newotshi ye-circadian yomzimba.

I-SR9009, eyaziwa ngokuba yi-Stenabolic, lichiza lophando njenge-agonist ye-REV-ERB.
I-REV-ERB-α kunye ne-REV-ERB-β, ii-receptors ezimbini zenyukliya, zinendima ebalulekileyo ekulawuleni ukubonakaliswa kweeprotheni zewashi eziphambili eziqhuba izigqi kumsebenzi kunye nemetabolism.
I-In vitro: Zombini i-SR9009 kunye ne-analog SR9011 yayo inokunyusa idosi-exhomekeke kwi-REV-ERB-into yokucinezela ehlolwe kwiiseli ze-HEK293 ezibonisa isizinda esibophelelayo se-Gal4 DNA: i-REV-ERB i-ligand ebophelelayo idomeyini i-α okanye i-β kunye nengxelo ye-luciferase ephendulayo ye-Gal4. .Ukongeza, i-SR9009 yafunyanwa ikwazi ukucinezela i-BMAL1 isithunywa se-RNA intetho kwiiseli ze-HepG2 ngendlela ye-REV-ERB-α/β-exhomekeke.
Kwi-vivo: Iigundane ziphathwe ngedosi enye ye-SR9009, i-SR9011 okanye isithuthi ngexesha le-circadian 6 (CT6 (6h emva kokukhanyisa) emva kweentsuku ze-12 kwiimeko ze-D / D ezibonisa ukubonakaliswa okuphezulu kwe-Rev-erb-α. Iziphumo zibonise ukuba isithuthi Isitofu abangelanga siphazamiso kumsebenzi we-circadian locomotor Ngokwahlukileyo, ulawulo lwedosi enye nokuba yi-SR9009 okanye i-SR9011 ikhokelele ekuphulukaneni nomsebenzi welocomotor ngexesha lesigaba sobumnyama besifundo. Ukongeza, umsebenzi wesiqhelo ubuyise umjikelo olandelayo we-circadian, owawungaguquguquki. kunye nokukhutshwa kwamachiza ngaphantsi kwe-24h.