I-Agonist API GW501516 powder emhlophe

I-GW 501516 i-agonist ye-PPARδ enexabiso le-EC50 le-1.1 nM.
I-GW501516 iboniswa njengeyona nto inamandla kwaye ikhethiweyo ye-PPARα i-agonists eyaziwa nge-EC 50 ye-1. I-1 nM ngokumelene ne-PPARα kunye ne-1000-fold selectivity phezu kwezinye ii-subtypes zabantu, i-PPARα kunye -γ.I-GW501516 yenza iziphumo zokuchasana nokudumba kwiiseli ze-mouse ezikhuliswe kwiproximal tubular (mProx).I-GW501516 inqanda ukunyuka kwe-palmitate- kunye ne-TNFα-induced in MCP-1 mRNA expression ngendlela exhomekeke kwidosi.
I-GW501516 ibangela ukungahambi kakuhle kwamathambo, okukhokelela ekunciphiseni i-BMD kunye nokuwohloka kweempawu zethambo kwiigundane ze-OVX.I-GW501516 inciphisa ukudumba kwe-interstitial kunye nomonakalo weseli ye-tubula yeproximal kwiprotheni-overload mouse nephropathy model.Unyango lwe-GW501516 luphucula ukuqhuba ukunyamezela kunye nomlinganiselo we-succinate dehydrogenase (SDH) -i-fiber muscle emihle kuzo zombini iigundane eziqeqeshiweyo nezingaqeqeshwanga.