Prostaglandins Chemical imveliso 99% ubumsulwa API Material Lumigan Bimatoprost CAS 155206-00-1 ukunyanga iliso
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Ukusetyenziswa
I-Bimatoprost lichiza le-prostaglandin elaqala ukusetyenziswa ukunyanga izifo zamehlo ezifana ne-glaucoma.Igama lechiza nguLumigan.Nangona kunjalo, ngexesha lonyango, isigulane safumanisa ngokungalindelekanga ukuba ububanzi, ubude kunye nokuxinana kwee-eyelashes zakhe kuye kwanda kakhulu.Emva koko, i-bimatoprost isetyenziswe kwizilingo zeklinikhi zobuhle be-eyelash.Umphumo wayo omkhulu ekukhuleni kunye nokuqina kwe-eyelashes ngokuthe ngqo kwakhokelela ekuqalisweni kweLattise yinkampani yokuvelisa iLumegen, i-Allergan.Ichiza laqaliswa ngoDisemba 2008. Ivunywe yi-US FDA, ibe yimveliso yobungcali yokwenza i-eyelashes ibe mnyama kunye nokujiya.
NgoJulayi 2006, i-bimatoprost-timolol maleate i-compound eye drops eye yaphuhliswa yi-United States Allergan Co., Ltd. yavunywa ligunya le-pharmaceutical ye-EU yokunciphisa impendulo kwi-block blocker ye-β-receptor okanye i-prostaglandins.Uxinzelelo lwe-intraocular okanye uxinzelelo lwe-ocular kwizigulane ezine-glaucoma evulekileyo engaphenduli ngokwaneleyo kunyango lwe-analog.I-compound eye drops iqulethe i-0.0Chemicalbook3% bimatoprost kunye ne-0.5% ye-timolol maleate, kanye ngosuku, inokubonelela ngonyango olusebenzayo kakhulu lwe-intraocular control effect, kwaye umphumo ungcono kune-bimatoprost yodwa.Matoprost okanye timolol maleate.Ulingo lwezonyango luqinisekisile ukuba iyeza linokunyamezela okugqwesileyo, kubandakanywa nokunciphisa i-40% kwisiganeko se-ocular hyperemia xa kuthelekiswa ne-bimatoprost yodwa.
Kunyango lwe-glaucoma, ingasetyenziselwa kulwelo lokukhula kwe-eyelash, ugxininiso ngu-0.03%.
Iinkcukacha
| Igama lemveliso | Bimatoprost |
| CAS | 155206-00-1 |
| Ukuxinana | 1.1 ± 0.1 g/cm3 |
| Indawo yokubilisa | 629.8 ± 55.0 ° C AT 760 mmHg |
| Indawo yokunyibilika | 66-68 ° C |
| Imolekyuli | C25H37NO4 |
| Ubunzima bemolekyuli | 415.566 |
| Indawo yokuflasha | 334.7 ± 31.5 ° C |
| Umgangatho ochanekileyo | 415.272247 |
| PSA | 89.79000 |
| Ilog | 1.98 |
| Imbonakalo | ICrystal Solid |
| Uxinzelelo lomphunga | 0.0 ± 1.9 mmHg AT 25 ° C |
| Isalathiso sokuqhafaza | 1.591 |
| Iimeko zokugcina | 20 °C |
Ezinye zeBimatoprost CAS 155206-00-1 Uphando:
I-Olaparib yayisebenza ngokuchasene ne-Brca1; ii-p53 zebele zesisu (50mg/kg inaliti ye-intraperitoneal ngosuku), kodwa ayizange ibe nempembelelo kwi-HR-i-Ecad esweleyo; i-p53 yebele yamathumba.I-Olaparib yayingenayo i-dose-liming toxicity kwiigundane ezine-tumor.I-Olaparib isetyenziselwe ukunyanga amathumba kunye nokuguqulwa kwe-BRCA, njengomhlaza we-ovarian, umhlaza webele, kunye nomhlaza we-prostate.Ukongeza, i-Olaparib ithintele iiseli ze-tumor ezinqongopheleyo ze-ATM ngokukhethayo, icebisa ukuba i-Olaparib ingasetyenziswa njengearhente enokubakho kunyango lwe-ATM-mutated lymphoid tumors.
I-Olaparib yi-PARP inhibitor ekwasebenza ngokuchasene nokuguqulwa kwe-BRCA1 okanye i-BRCA2.I-Olaparib inempembelelo encinci kwi-tanky (polymer) i-enzyme-1, kwaye ixabiso le-IC50 likhulu kunoko.I-Olaparib kwi-concentration ye-30-100nM isebenza kwiiseli ze-SW620 ukuze ingasebenzi i-PARP-1.Imigca yeeseli ezinqongopheleyo ze-BRCA1 (i-MDA-MB-463 [1] kunye ne-HCC1937) i-hypersensitive kwi-Olaparib xa ithelekiswa ne-BRCA1- kunye ne-BRCA2-yaneleyo yemigca yeseli (Hs578T, MDA-MB-23, T47D) I-Olaparib inqanda i-PARP kunye nokulungiswa kwesiseko , okubangela uvakalelo olunamandla lweeseli ze-KB2P kwi-Olaparib.Isiphumo kukuguqulwa kwekhefu le-single-strand ukuya kwi-double-strand breaks ngexesha lokuphindaphinda kwe-DNA, ngaloo ndlela kusebenze indlela yokudibanisa exhomekeke kwi-BRCA2.
I-Bimatoprost yi-synthetic prostamide F2α derivative, enokukhetha ukulinganisa umphumo we-prostamine eveliswa emzimbeni, ukwandisa izinga lokuveliswa kwe-humor, ukunciphisa ukuchasana kokuphuma kwe-humor, kunye nokwandisa i-trabecular network channel kunye ne-uveal sclera. ibe lichiza lendawo elichasene neglaucoma elinesiphumo esinamandla sokunciphisa uxinzelelo lwe-intraocular.Ilungele unyango lwe-open-angle glaucoma (POAG) okanye amehlo aphezulu angasebenziyo kunye namanye amachiza okunciphisa uxinzelelo lwe-intraocular.Uxinzelelo lwegazi (OHT) izigulane.
Qaphela:
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