Imveliso yeMichiza iBromazolam CAS 71368-80-4
Ulwazi olusisiseko
Ifomula yemolekyuli: C17H13BrN4
- Indawo yokunyibilika: 272.0-275℃
- Indawo yokubila: 519.8±60.0 °C(Kuqikelelwe)
- uxinano: 1.54±0.1 g/cm3 (20 ºC 760 Torr)
- pka: 2.37±0.40(Kuxelwe kwangaphambili)
- Ifomula yemolekyuli: C17H13BrN4
- Ubunzima beMolekyuli: 353.21600
- Ubunzima obuchanekileyo: 352.03200
- PSA: 43.07000
- LogP: 3.12480
Ukusetyenziswa
I-Bromazolam ihlelwa njengenoveli ye-benzodiazepine eyaqala ukwenziwa ngo-1976, kodwa ayizange ithengiswe.Emva koko ithengiswe njengechiza lomyili, okokuqala ichongiwe ngokuqinisekileyo yi-EMCDDA eSweden ngo-2016. Yi-bromo endaweni ye-chloro analogue ye-alprazolam, kwaye ineempembelelo ezifanayo zokuthoba kunye ne-anxiolytic.I-Bromazolam i-structural efana ne-benzodiazepines yendabuko, kuquka i-alprazolam (ukutshintsha i-chlorine nge-bromine) kunye ne-bromazepam (ukongezwa kweringi ye-triazole).I-Alprazolam kunye ne-bromazepam zizinto zeShedyuli ye-IV e-United States;I-bromazolam ayicwangciswanga ngokucacileyo.
I-8-Bromo-1-methyl-6-phenyl-4H-s-triazolo [4,3-a] [1,4] i-benzodiazepine isetyenziselwa ukufunda umsebenzi wokulwa nokukhathazeka, i-anti-depressant kunye ne-psychotropics kwinkqubo ye-nervous central.
Indlela Yokulungiselela
Baye baphathwa nge-PHLS9 (2 mg protein / mL), 25 μg/mL Alamethicin (UGT reaction umxube B), 90 mM phosphate buffer (pH 7.4), 2.5 mM mg 2+, 2.5 mM isocitrate, kunye ne-0.6 mM kwi-37 ° C NADP +, 0.9 U / mL isocitrate dehydrogenase, 100 U / mL superoxide dismutase kunye ne-0.1 mM acetyl-CoA.Emva koko, i-2.5 mM UDP-glucuronic acid (i-UGT reaction mix solution A), 40 μM PAPS, 1.2 mM SAM, 1 mM dithiothreitol, 10 mM glutathione, kunye ne-50 μM clobromazolam okanye iBromazolam zongezwa.
Iimeko zokusabela:I-50 μM i-Bromazolam ye-360min kwi-37 ° C
Usetyenziso:Iimetabolites zeBromazolam zazinjaloichongiwekwi-PHLS9 incubation.