NEUROPEPTIDE FF CAS:99566-27-5 PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE AMIDE PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2 NPFF NEUROPEPTIDE FF

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NOMORO YA CAS:99566-27-5

Lebitso:NEUROPEPTIDE FF

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Tšebeliso

NPFF Neuropeptide (FLFQPQRFa) ke mammalian aminated neuropeptide qalong e neng e ikarotse bokong ba likhomo 'me e tsebahala e le peptide e laolang bohloko e nang le tšebetso ea antiopioid ho ea ho analgesia e bakoang ke morphine.

Ho batho, neuropeptide FF peptide e kentsoe ke NPFF gene.Liphatsa tsa lefutso tse peli tse kenyelletsang li-receptor tse peli tse fapaneng (NPFF1 le NPFF2) le li-precursors tse peli (NPFFA le NPFFB) li entsoe ka liphoofolo tse 'maloa.

Neuropeptide FF (NPFF) le li-peptide tse amanang le RFamide tse hlahisoang ke li-precursors tse peli li sebelisana le li-subtypes tse peli tsa G-protein-coupled receptors, li-subtypes tsa NPFF1 le NPFF2, tse nang le kamano e ntle 'me li ameha mesebetsing e fapaneng ea 'mele, e kang ho laola pelo le methapo, taolo ea li-hormone, ts'ebetso ea macrophage, thermohomeostasis, le taolo ea bohloko.

Kalafo ea selelekela sa NPFFA sebakeng sa motheo sa proteolytic e lokela ho fana ka peptide e nang le NPFF, e nang le li-amino acid tse tharo tse eketsehileng tse fapaneng ho ea ka mefuta ho ea ka mefuta, le peptide e nang le NPSF (SLAAPQRFa), eo bolelele ba eona bo itšetlehileng ka mefuta.NPFFB e khethiloe e le selelekela sa peptide e amanang le RFamide (RFRP, eo hape e tsejoang e le GnIH ea gonadotropin-suppressing hormone), e nang le li-peptide tse nang le LPLRFa le li-peptide tse arolelanang moelelo o tšoanang oa C-terminal PQRFamide joaloka NPFF, joalo ka NPVF (VPNLPQRFa) motho.

Litsamaiso tsa NPFF le opioid li bontšitsoe ho sebelisana maemong a mangata, ho tloha boitšoarong ba liphoofolo ho ea ho limolek'hule tsa receptor.Nociception ke ts'ebetso ea 'mele e ithutoang ka ho fetesisa ea tšebelisano ena, empa moputso, motsamao, ho ja le ho sisinyeha ha mala le tsona lia ameha.Li-opioid tsa Endogenous li hlokeha bakeng sa thepa ea analgesic ea ente ea mokokotlo ea NPFF, 'me li-peptide tsa NPFF tse sa feleng li ameha ts'ebetsong ea ho mamellana ha bohloko / hyperalgesia e bakoang ke phekolo e sa foleng ea opioid.

NPFF e boetse e laola palo le metabolism ea macrophages meleng ea adipose, e leng bohlokoa bakeng sa bophelo bo botle ba lisele tsa adipose.