Hygromycin A CAS: 6379-56-2 Homomycin
Ikopanye le 'na
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Lintho tsa Lik'hemik'hale:
Phofo e tšoeu.Acid e fokolang.Ho qhibiliha ka bolokolohi metsing le joala.E hlahisoa ke Streptomyces hygroscopicus.
Lisebelisoa:
Hygromycin A, lithibela-mafu tse hlokomolohuoang, ka ho khetha li bolaea libaktheria tse bakang lefu la Lyme.E ile ea khona ho phekola lefu la Lyme ho litoeba ntle le ho senya microbiome.
Meriana (thibela-mafu e pharalletseng).
Tlhaloso ChEBI: Sehlahisoa sa tlhaho se fumanoang mefuteng ea Streptomyces.
SR 9009 ke agonist ea maiketsetso ea REV-ERB e laolang boitšoaro ba circadian le metabolism;e ka sebelisoa ho phekola mathata a ho robala le mafu a metabolism.Ke motsoako oa lead bakeng sa sehlopha se secha sa lithethefatsi tsa mofetše tse amanang le oache ea potoloho ea 'mele.
SR9009, e tsejoang hape e le Stenabolic, ke sethethefatsi sa lipatlisiso e le agonist ea REV-ERB.
REV-ERB-α le REV-ERB-β, li-receptor tse peli tsa nyutlelie, li na le karolo ea bohlokoa ho laoleng polelo ea liprotheine tsa lioache tsa mantlha tse tsamaisang morethetho tšebetsong le metabolism.
In vitro: Ka bobeli SR9009 le analoge ea eona SR9011 li ka eketsa ts'ebetso ea khatello e itšetlehileng ka REV-ERB e lekotsoeng ka liseleng tsa HEK293 tse hlalosang sebaka se tlamang sa Gal4 DNA: REV-ERB ligand ligand domain α kapa β le motlalehi oa luciferase oa Gal4. .Ho phaella moo, SR9009 e fumanoe e khona ho hatella polelo ea BMAL1 lenģosa la RNA liseleng tsa HepG2 ka mokhoa o itšetlehileng ka REV-ERB-α / β.
In vivo: Litoeba li ne li tšoaroa ka tekanyo e le 'ngoe ea SR9009, SR9011 kapa koloi ka nako ea circadian 6 (CT6 (6h ka mor'a mabone) ka mor'a matsatsi a 12 maemong a D/D a bontšang pontšo ea tlhōrō ea Rev-erb-α. Liphello li bontšitse koloi eo Ka lehlakoreng le leng, tšebeliso ea tekanyo e le 'ngoe ea SR9009 kapa SR9011 e lebisitse tahlehelong ea ts'ebetso ea li-locomotor nakong ea lefifi la thuto. ka tumello ea lithethefatsi ka nako e ka tlase ho lihora tse 24.
