Agonist API GW501516 phofo e tšoeu
Ikopanye le 'na
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Tšebeliso
GW 501516 ke agonist ea PPARδ e nang le boleng ba EC50 ba 1.1 nM.
GW501516 e bontšoa e le li-agonists tse matla ka ho fetisisa le tse khethiloeng tsa PPARα tse tsejoang ka EC 50 ea 1. 1 nM khahlanong le PPARα le 1000-fold selectivity holim'a mefuta e meng ea batho, PPARα le -γ.GW501516 e na le litlamorao tse khahlanong le ho ruruha ho li-cell proximal tubular (mProx) tsa mouse.GW501516 e thibela ho eketseha ha palmitate- le TNFα-induced ho polelo ea MCP-1 mRNA ka mokhoa o itšetlehileng ka tekanyo.
GW501516 e baka ho senyeha ha masapo, ho lebisang ho fokotseha ha BMD le ho senyeha ha masapo ho likhoto tsa OVX.GW501516 e thibela ho ruruha ha li-interstitial le tšenyo ea sele ea proximal tubular ka mokhoa oa protheine-overload mouse nephropathy.Phekolo ea GW501516 e ntlafatsa mamello ea ho matha le karolo ea succinate dehydrogenase (SDH) -li-fibers tse ntle tsa mesifa ho litoeba tse koetlisitsoeng le tse sa koetlisoang.
Litlhaloso
| Lebitso le tloaelehileng | GW-501516 | Lebitso la Senyesemane | GW501516 |
| Nomoro ea CAS | 317318-70-0 | boima ba molek'hule | 453.498 |
| tekano | 1.4±0.1 g/cm3 | ntlha e belang | 584.5±60.0 °C ho 760 mmHg |
| foromo ea limolek'hule | C21H18F3NO3S2 | ntlha e qhibidihang | 134-136°C |
| PSA | 112.96000 | flash point | 307.3±32.9 °C |