Prostaglandins Chemical sehlahisoa 99%purity API Material Lumigan Bimatoprost CAS 155206-00-1 bakeng sa ho phekola mahlo
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Tšebeliso
Bimatoprost ke sethethefatsi sa prostaglandin se qalileng ho sebelisoa ho phekola mafu a mahlo a kang glaucoma.Lebitso la lithethefatsi ke Lumigan.Leha ho le joalo, nakong ea phekolo, mokuli o ile a fumana ka tšohanyetso hore bophara, bolelele le boima ba li-eyelashes tsa hae li eketsehile haholo.Kamora moo, bimatoprost e ile ea sebelisoa litekong tsa bongaka bakeng sa botle ba lintši.Phello ea eona e kholo ea li-eyelashes tse teteaneng le tse teteaneng ka ho toba li lebisitse ho qalisoa ha Lattise ke k'hamphani ea tlhahiso ea Lumegen, Allergan.Setlhare sena se ile sa qalisoa ka December 2008. E amohetsoe ke US FDA, e fetohile sehlahisoa sa setsebi bakeng sa ho ntšoa le ho teteka ha li-eyelashes.
Ka July 2006, marotholi a mahlo a bimatoprost-timolol maleate a kopantsoeng a entsoeng ke United States Allergan Co., Ltd. e ile ea amoheloa ke bolaoli ba meriana ea EU bakeng sa ho fokotsa karabelo ea tšebeliso e le 'ngoe ea li-β-receptor blockers kapa prostaglandins.Khatello ea methapo ea methapo kapa khatello ea mali ea mahlo ho bakuli ba nang le glaucoma e bulehileng ba sa arabeleng ka mokhoa o lekaneng kalafong ea analog.Marotholi a mahlo a kopantsoeng a na le 0.0Chemicalbook3% bimatoprost le 0.5% timolol maleate, hanngoe ka letsatsi, e ka fana ka phello ea kliniki e sebetsang haholo ea khatello ea methapo ea methapo, 'me phello e molemo ho feta ea bimatoprost feela.Matoprost kapa timolol maleate.Liteko tsa bongaka li netefalitse hore moriana o na le mamello e ntle haholo, ho kenyelletsa le phokotso ea 40% ea sekhahla sa hyperemia ea mahlo ha e bapisoa le bimatoprost feela.
Bakeng sa kalafo ea glaucoma, e ka sebelisoa hape ho mokelikeli oa kholo ea eyelash, mahloriso ke 0.03%
Litlhaloso
| Lebitso la Sehlahiswa | Bimatoprost |
| CAS | 155206-00-1 |
| Botenya | 1.1 ± 0.1 g/cm3 |
| Ntho e belang | 629.8 ± 55.0 ° C AT 760 mmHg |
| Sebaka se qhibilihang | 66-68 ° C |
| Molek'hule | C25H37NO4 |
| Boima ba molek'hule | 415.566 |
| flash point | 334.7 ± 31.5 ° C |
| Boleng bo Nepahetseng | 415.272247 |
| PSA | 89.79000 |
| Logp | 1.98 |
| Ponahalo | Crystal e tiileng |
| Khatello ea mouoane | 0.0 ± 1.9 mmHg KA 25 ° C |
| Lenane la refractive | 1.591 |
| Maemo a polokelo | 20 ° C |
Lipatlisiso tse ling tsa Bimatoprost CAS 155206-00-1:
Olaparib e ne e sebetsa kgahlanong le Brca1;p53 matsoele ente (50mg/kg intraperitoneal ente ka letsatsi), empa e ne e se na phello ho HR-deficient Ecad;p53 matsoele a matsoele.Olaparib e ne e se na chefo e fokotsang tekanyetso ho litoeba tse nang le tumor.Olaparib e 'nile ea sebelisoa ho phekola lihlahala ka liphetoho tsa BRCA, tse kang kankere ea mahe a bomme, mofetše oa matsoele le mofetše oa senya.Ho feta moo, Olaparib e ile ea thibela lisele tsa hlahala tse haelloang ke ATM ka mokhoa o ikhethileng, e fana ka maikutlo a hore Olaparib e ka sebelisoa e le moemeli oa kalafo ea lihlahala tsa lymphoid tse fetotsoeng ke ATM.
Olaparib ke PARP inhibitor hape e sebetsa khahlano le liphetoho tsa BRCA1 kapa BRCA2.Olaparib e na le phello e fokolang ho tanky (polymer) enzyme-1, 'me boleng ba IC50 bo boholo ho feta moo.Olaparib sebakeng sa 30-100nM e sebetsa liseleng tsa SW620 ho etsa hore PARP-1 e sebetse.BRCA1-deficient cell line (MDA-MB-463[1] le HCC1937) e na le hypersensitive ho Olaparib ha e bapisoa le BRCA1- le BRCA2-sufficient cell line (Hs578T,MDA-MB-23,T47D) Olaparib e thibela PARP le ho thibela ho lokisoa ha motheo. , e hlahisang kutloisiso e matla ea lisele tsa KB2P ho Olaparib.Sephetho ke phetoho ea likheo tsa khoele e le 'ngoe ho ea ho likheo tse habeli nakong ea phetisetso ea DNA, ka hona ho kenya tšebetsong tsela ea ho kopanya e itšetlehileng ka BRCA2.
Bimatoprost ke motsoako oa prostamide F2α, o ka khethang ho etsisa phello ea prostamine e hlahisoang 'meleng, ho eketsa sekhahla sa tlhahiso ea metlae ea metsi, ho fokotsa khanyetso ea metsi a monate, le ho eketsa mocha oa marang-rang oa trabecular le uveal sclera. e be sethethefatsi sa lehae sa anti-glaucoma se nang le phello e matla ho fokotsa khatello ea methapo ea kutlo.E loketse bakeng sa kalafo ea open-angle glaucoma (POAG) kapa mahlo a phahameng a sa sebetseng le lithethefatsi tse ling tsa intraocular tse theolang khatello.Bakuli ba khatello ea mali (OHT).
Ela hloko:
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