NeuropeptIDE FF CAS:99566-27-5 PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE AMIDE PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2 NPFF NEUROPEPTIDE FF
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NPFF Neuropeptide (FLFQPQRFa) waa naasleey naaslay neuropeptide asal ahaan ka go'doonsan maskaxda lafaha waxaana lagu gartaa sida peptide xanuunka xakameynaya oo leh firfircoonida antiopioid ilaa xanuunka morphine-ku keeno.
Bini'aadamka, neuropeptide FF peptide waxaa lagu calaamadeeyay hidda-wadaha NPFF.Laba hidde-sideeyaal laba nooc oo kala duwan ah (NPFF1 iyo NPFF2) iyo laba horudhac (NPFFA iyo NPFFB) ayaa lagu xidhay dhowr naasley.
Neuropeptide FF (NPFF) iyo RFamide peptides la xidhiidha oo ay soo saaraan laba horudhac ayaa la falgala labada nooc ee G-protein-ku-xidhan-qabayaasha, NPFF1 iyo NPFF2 subtypes, oo leh xiriir wanaagsan waxayna ku lug leeyihiin noocyo kala duwan oo hawlo jireed, sida nidaaminta wadnaha, xakamaynta hoormoonka, firfircoonida makrophage, thermohomeostasis, iyo xakamaynta xanuunka.
Daawaynta horudhaca NPFFA ee goobta asaasiga ah ee proteolytic waa in ay soo saartaa peptide ka kooban NPFF, oo leh saddex dheeraad ah oo N-terminal amino acids kuwaas oo ku kala duwan noocyada noocyada, iyo peptide ka kooban NPSF (SLAAPQRFa), oo dhererkiisu ku xiran yahay noocyada.NPFFB waxaa loo aqoonsaday inuu yahay horudhaca RFamide ee peptide (RFRP, oo sidoo kale loo yaqaan GnIH of gonadotropin-suppressing hormone), oo ka kooban peptides ka kooban LPLRFa iyo peptides oo wadaagaya isla C-terminal PQRFamide motif sida NPFF, sida NPVF (VPNLPQRFa) aadanaha.
Nidaamyada NPFF iyo opioid ayaa la muujiyey inay is dhexgalaan heerar kala duwan, laga bilaabo dabeecadda xayawaanka ilaa unugyaraha soo-dhoweynta.Nociception waa shaqada physiological ee ugu badan ee la bartay ee isdhexgalkan, laakiin abaalmarinta, dhaqdhaqaaqa, cunista iyo dhaqdhaqaaqa saxarada ayaa sidoo kale saameeya.opioids endogenous ayaa looga baahan yahay sifooyinka xanuunka ee cirbadeynta laf dhabarta ee NPFF, iyo NPFF peptides endogenous waxay ku lug leeyihiin habka dulqaadka xanuunka / hyperalgesia ee ay keentay daaweynta opioid dabadheeraad ah.
NPFF waxay sidoo kale xakameysaa tirada iyo dheef-shiid kiimikaadka makrophages ee unugyada adipose, taas oo lagama maarmaan u ah caafimaadka unugyada adipose.
