HU-210 CAS NO: 112830-95-2

HU-210 waa (-) enantiomer 11-OH-D 8-THC-DMH, kaas oo leh ku dhawaad ​​dhammaan hawlaha cannabinoids, halka (+) entiomer, oo loo yaqaan HU-211, uu yahay mid aan firfircoonayn sida cannabinoid, laakiin u dhaqmo halkii cannabinoid sida NMDA antagonist oo leh saameyn neuroprotective.

HU-210 waxaa laga yaabaa inay kor u qaaddo kororka, laakiin maaha kala duwanaansho, unugyada asliga ah ee hippocampal embriyaha ee hiddaha iyo unugyada horudhaca ah iyadoo la kicinayo CB 1 reseptor, G i / o borotiinka, iyo calaamadaha ERK si isdaba joog ah.Kordhinta korriinka dareemayaasha ayaa sidoo kale tilmaamaya baahida loo qabo ka-hortagga walaaca iyo saameynta niyad-jabka.

Si wada jir ah cannabinoids kale ee synthetic, sida WIN 55,212-2 iyo JWH-133, HU-210 waxay ka ilaalisaa caabuqa ay keento cudurka Alzheimers ee la xidhiidha beta amyloid, marka lagu daro ka hortagga garashada garashada iyo luminta calaamadaha neuronal.Saamayntan ka-hortagga-bararka waxaa keenaya kicinta cannabinoid reseptors, taas oo ka hortagaysa firfircoonida unugyada microglia bararka.Intaa waxaa dheer, cannabinoids waxay si buuxda u tirtirtay neurotoxicity ee la xidhiidha firfircoonida unugyada microglial ee moodooyinka jiirka.

HU-210 waa xanuun baabiiye awood leh oo leh saameyn badan oo la mid ah THC dabiiciga ah.

LD50 afka laga qaato ee HU-210 waa 5,000mg/kg jiirka iyo 14,200mg/kg ee bakaylaha.LDLO (qiyaasta ugu yar ee dilaaga ah) ee HU-210 ee bini'aadamka waa 143mg/kg.LD50 ee kafeyn waxa lagu qiyaasay 150-200 mg/kg.Delta-8-THC LD50 lama xaqiijinDaraasad 1973-dii, daanyeerka iyo eeyaha la siiyay 9,000 mg/kg Delta-8-THC waxay ahaayeen kuwo aan dilaa ahayn.