Agonist API GW501516 budo cad
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Isticmaalka
GW 501516 waa agonist PPARδ leh EC50 oo qiimaheedu yahay 1.1 nM.
GW501516 waxaa lagu muujiyey inay yihiin kuwa ugu awoodda badan uguna xulashada PPARA agonists ee loo yaqaan EC 50 ee 1. 1 nM oo ka soo horjeeda PPARA iyo 1000-laab xulashada noocyada kale ee aadanaha, PPARA iyo -γ.GW501516 waxay ku fulisaa saamaynta anti-bararka ee unugyada tubular proximal (mProx).GW501516 waxay joojisaa palmitate-iyo TNFa-ku-kordhinta muujinta MCP-1 mRNA ee habka qiyaasta-ku-tiirsanaanta.
GW501516 waxay sababtaa samaynta lafaha daciifka ah, taasoo keentay hoos u dhaca BMD iyo xumaanshaha hantida lafaha ee jiirka OVX.GW501516 waxay yaraynaysaa caabuqa interstitial iyo dhaawaca unugyada tubaakada ee u dhow ee moodeelka nephropathy mouse mouse.Daawaynta GW501516 waxay wanaajisaa adkaysiga socodka iyo saamiga succinate dehydrogenase (SDH) -fiyuusyada murqaha togan ee jiirarka tababbaran iyo kuwa aan tababaran labadaba.
Tilmaamaha
| Magaca guud | GW-501516 | Magaca Ingiriisiga | GW501516 |
| Lambarka CAS | 317318-70-0 | miisaanka kelli | 453.498 |
| cufnaanta | 1.4±0.1 g/cm3 | barta karkaraya | 584.5± 60.0 °C at 760 mmHg |
| caanaha molecular | C21H18F3NO3S2 | barta dhalaalaysa | 134-136°C |
| PSA | 112.96000 | barta toosan | 307.3± 32.9 °C |