Xylazine CAS NO: 7361-61-7 Rompun, Anased, Sedazine, Chanazine

Kushandiswa kwekurapa
Toluene thiazide inowanzoshandiswa sedative, muscle relaxant uye analgesic.Inowanzoshandiswa kurapa tetanus.Xylazine inonyanya kufanana nemishonga yakadai se phenothiazine, tricyclic antidepressants uye clonidine.Seanesthetic, inowanzoshandiswa pamwe chete neketamine.Xylazine inoratidzika kuderedza kunzwisiswa kwemuviri kune insulini uye glucose kutora.Yohimbine ndeye alpha2 adrenergic receptor antagonist iyo yakashandiswa kuderedza mazinga eglucose kusvika kune hutano.Yohimbine inodzoreredza mhedzisiro ye toluene thiazide munzvimbo yekiriniki kana ikabatwa intravenous nguva pfupi mushure mekupihwa toluene thiazide.

pharmacodynamics

Xylazine ine simba alpha 2 adrenergic agonist.Toluene thiazide nemamwe alpha2 adrenergic receptor agonists anogoverwa mumuviri wese mukati me30-40 maminetsi kana apihwa.Nekuda kweiyo yakakwira lipophilicity, toluene thiazide inokurudzira zvakananga pakati α2 receptors pamwe neperipheral αadrenergic receptors mumhando dzakasiyana siyana.Semunhu anopikisa, toluene thiazide inoguma nekuderedzwa kweurotransmission ye norepinephrine uye dopamine mukatikati metsinga.Inoita izvi nekutevedzera kusungwa kwe norepinephrine kune autoreceptors pane presynaptic surface, izvo zvinoguma nemhinduro inhibition ye norepinephrine.

Xylazine inoshandawo sekutakura inhibitor nekudzivisa norepinephrine kutakura basa kuburikidza nemakwikwi inhibiting substrate transport.Saka, toluene thiazide yakawedzera zvakanyanya K m uye haina kukanganisa V max.Izvi zvinogona kuitika kuburikidza nekudyidzana kwakananga nematunhu anopindirana nemasaiti ekusunga anodzvinyirira.Semuenzaniso, toluene thiazide uye clonidine inhibisa kutora kweMIBG (anorepinephrine analogue) nemasero euroblastoma.Xylazine ine hukama hwakasiyana hwecholinergic, serotonergic, dopaminergic, alpha1, adrenergic, H 2-histamine, uye opioid receptors.Chimiro chayo chemakemikari chakafanana zvikuru neye phenothiazines, tricyclic antidepressants uye clonidine