JWH18 Jwh18 5cl Sgt78 7A 7ad Adb S709 CAS 209414-07-3

JWH-018 (1-pentyl-3- (1-naphthoyl) indole, NA-PIMO kana AM-678) ikemikari yeanalgesic mumhuri ye naphthoyl indole, iyo inoratidzwa muCB 1 uye CB 2 cannabinoid receptors, Ine zvimwe. selectivity for CB 2. Inobudisa migumisiro mumhuka dzakafanana neTHC, cannabinoid inowanikwa zvakasikwa mu cannabis, zvichiita kuti ishandiswe muzvigadzirwa zvekugadzira cannabis, izvo mune dzimwe nyika zvinotengeswa zviri pamutemo se "kunhuhwirira kusanganiswa."

Semugadziri akazara weCB 1 uye CB 2 cannabinoid receptors, komisheni iyi inorongedzerwa seanonyaradza marwadzo.Iyo analgesic mhedzisiro ye cannabinoid ligands inopindirana neCB1 receptors yakanyatso kuratidzwa mukurapa kweuropathic kurwadziwa, kenza kurwadziwa, uye arthritis.

Makomponi aya anoshanda nekutevedzera masikirwo emumuviri endocannabinoid mahormone, akadai se2-AG uye anandamide (AEA), ayo anoshanda biologically uye anogona kuwedzera kana kuvharidzira kusaina kwetsinga.Nemhaka yokuti zvishoma zvinozivikanwa pamusoro pezvikonzero zvinokonzera kurwadziwa kusingaperi, kutsvakurudza kwakawanda uye kubudirira kunofanira kuitwa kusati kwaitika simba rekurapa remishonga yakadaro yehupenyu inogona kuitika.