Agonist API GW501516 chena poda
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Usage
GW 501516 iagonist yePPARδ ine EC50 kukosha kwe1.1 nM.
GW501516 inoratidzwa kuva yakanyanya simba uye inosarudza PPARα agonists inozivikanwa neEC 50 ye 1. 1 nM inopesana nePPARα uye 1000-fold selectivity pane mamwe ma subtypes evanhu, PPARα uye -γ.GW501516 inoshandisa anti-inflammatory effects mu mouse cultured proximal tubular (mProx) masero.GW501516 inhibits palmitate- uye TNFα-induced kuwedzera muMCP-1 mRNA kutaura mune imwe nzira-inotsamira.
GW501516 inokonzera kukanganisa kuumbwa kwemapfupa, zvichiita kuti kuderera kweBMD uye kuparara kwemapfupa emapfupa mumakonzo eOVX.GW501516 inoderedza kuzvimba kwepakati uye proximal tubular cell kukuvara muprotein-overload mouse nephropathy modhi.GW501516 kurapwa kunowedzera kumhanya kutsungirira uye chikamu che succinate dehydrogenase (SDH) -positive muscle fibers mumakonzo akadzidziswa uye asina kudzidziswa.
Zvinotsanangurwa
| Common name | GW-501516 | Zita rechirungu | GW501516 |
| CAS nhamba | 317318-70-0 | molecular uremu | 453.498 |
| density | 1.4±0.1 g/cm3 | boiling point | 584.5±60.0 °C pa760 mmHg |
| molecular formula | C21H18F3NO3S2 | melting point | 134-136°C |
| PSA | 112.96000 | flash point | 307.3±32.9 °C |