Prostaglandins Chemical chigadzirwa 99% kuchena API Material Lumigan Bimatoprost CAS 155206-00-1 yekurapa ziso
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Usage
Bimatoprost mushonga weprostaglandin wakatanga kushandiswa kurapa zvirwere zvemaziso zvakaita seglaucoma.Zita remushonga ndiLumigan.Nekudaro, panguva yekurapa, murwere akawana zvisingatarisirwi kuti dhayamita, kureba uye kuwanda kweeyelashes yake yakawedzera zvakanyanya.Mushure mezvo, bimatoprost yakashandiswa mumakiriniki ekuedzwa kwekunaka kwe eyelash.Mhedzisiro yayo yakakura pakukora uye kukora eyelashes yakanangana nekutangwa kweLattise nekambani yekugadzira yeLumegen, Allergan.Mushonga uyu wakatangwa muna Zvita 2008. Yakatenderwa neUS FDA, yave chigadzirwa chehunyanzvi chekusviba nekukora eyelashes.
Muna Chikunguru 2006, bimatoprost-timolol maleate madonhwe emeso akasanganiswa akagadzirwa neUnited States Allergan Co., Ltd. yakabvumidzwa neEU pharmaceutical authority yekudzikisa mhinduro kune imwechete-kushandisa β-receptor blockers kana prostaglandin.Intraocular pressure kana ocular hypertension muvarwere vane open-angle glaucoma vasingapindure zvakakwana kune analog therapy.Madonhwe emaziso emukomboni ane 0.0Chemicalbook3% bimatoprost uye 0.5% timolol maleate, kamwe chete pazuva, anogona kupa kliniki inoshanda zvakanyanya intraocular pressure control effect, uye mhedzisiro yacho iri nani pane iyo yebimatoprost chete.Matoprost kana timolol maleate.Miedzo yemakiriniki yakasimbisa kuti mushonga une kushivirira kwakanyanya, kusanganisira kuderedzwa kwe40% muchiitiko cheocular hyperemia kana ichienzaniswa nebimatoprost chete.
Kurapa kwe glaucoma, inogona zvakare kushandiswa mu eyelash kukura fluid, iyo yekumisikidza ndeye 0.03%
Zvinotsanangurwa
| Product Name | Bimatoprost |
| CAS | 155206-00-1 |
| Density | 1.1 ± 0.1 g/cm3 |
| Boiling point | 629.8 ± 55.0 ° C AT 760 mmHg |
| Melting point | 66-68 ° C |
| Molecular | C25H37NO4 |
| Molecular uremu | 415.566 |
| Flash point | 334.7 ± 31.5 ° C |
| Hunhu Hwakarurama | 415.272247 |
| PSA | 89.79000 |
| Logp | 1.98 |
| Chitarisiko | Crystal Solid |
| Steam pressure | 0.0 ± 1.9 mmHg PA25 ° C |
| Refractive index | 1.591 |
| Kuchengetedza mamiriro | 20 ° C |
Vamwe Bimatoprost CAS 155206-00-1 Tsvagiridzo:
Olaparib yaishanda kurwisa Brca1;p53 mazamu emazamu (50mg/kg intraperitoneal jekiseni pazuva), asi yakanga isina mhedzisiro paHR-inoshaya Ecad;p53 mazamu emazamu.Olaparib yakanga isina dose-inodzikamisa chepfu mumakonzo anotakura bundu.Olaparib yakashandiswa kurapa mapundu neBRCA mutations, senge kenza yeovarian, kenza yemazamu, uye kenza yeprostate.Mukuwedzera, Olaparib inhibited ATM-deficie bundu cells selectively, zvichiratidza kuti Olaparib inogona kushandiswa sechinhu chinogona kushandiswa pakurapa kweATM-mutated lymphoid tumors.
Olaparib iPARP inhibitor iyo inoshandawo zvinopesana neBRCA1 kana BRCA2 kuchinja.Olaparib haina mhedzisiro pa tanky (polymer) enzyme-1, uye kukosha kweIC50 kwakakura kupfuura izvozvo.Olaparib pakusangana kwe30-100nM inoita paSW620 maseru kuti isaite PARP-1.BRCA1-yakashomeka sero mitsara (MDA-MB-463 [1] uye HCC1937) ine hypersensitive kuOlaparib kana ichienzaniswa neBRCA1- uye BRCA2-yakakwana sero mitsara (Hs578T, MDA-MB-23, T47D) Olaparib inhibits PARP Repair uye inovhara base excision. , zvichiita kuti kuve nekunzwa kwakasimba kweKB2P masero kuOlaparib.Mhedzisiro ndeyekushandurwa kwekamwe-strand breaks kune kaviri-strand breaks panguva yekudzokororwa kweDNA, nekudaro kumisa iyo BRCA2-inotsamira recombination nzira.
Bimatoprost inogadzirwa prostamide F2α inotorwa, iyo inogona kusarudza kutevedzera maitiro eprostamine inogadzirwa mumuviri, kuwedzera chiyero cheaqueous kuseka kugadzirwa, kuderedza kuramba kweaqueous kuseka kubuda, uye kuwedzera trabecular network chiteshi uye uveal sclera Inofungidzirwa kuti iva mushonga wemuno unorwisa glaucoma une simba rakasimba rekudzikisa intraocular pressure.Inokodzera kurapwa kweyakavhurika-angle glaucoma (POAG) kana maziso epamusoro asingashande nemamwe madhiragi ekuderedza intraocular.Hypertension (OHT) varwere.
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