Kemikari chigadzirwa Bromazolam CAS 71368-80-4
Basic Information
Molecular formula: C17H13BrN4
- Kunyungudika: 272.0-275 ℃
- Poindi yekuvira: 519.8±60.0 °C(Zvakafanotaurwa)
- kuwanda: 1.54±0.1 g/cm3 (20 ºC 760 Torr)
- pka: 2.37±0.40(Zvakafanotaurwa)
- Molecular Formula: C17H13BrN4
- Molecular uremu: 353.21600
- Chaiyo Misa: 352.03200
- PSA: 43.07000
- LogP: 3.12480
Usage
Bromazolam inorongedzerwa sechinyorwa benzodiazepine iyo yakatanga kugadzirwa muna 1976, asi haina kumbobvira yatengeswa.Yakazotengeswa semushonga wekugadzira, kutanga ichinyatsozivikanwa neEMCDDA muSweden muna 2016. Ndiyo bromo panzvimbo ye chloro analogue yealprazolam, uye ine zvakafanana sedative uye anxiolytic madhara.Bromazolam yakarongeka yakafanana neyechinyakare benzodiazepines, kusanganisira alprazolam (inotsiva chlorine nebromine) uye bromazepam (wedzero yetriazole ring).Alprazolam uye bromazepam zvinhu zveChirongwa IV muUnited States;bromazolam haina kurongwa zvakajeka.
8-Bromo-1-methyl-6-phenyl-4H-s-triazolo [4,3-a] [1,4] benzodiazepine inoshandiswa kudzidza basa rekurwisa kuzvidya mwoyo, antidepressant uye psychotropics yepakati tsinga system.
Kugadzirira Nzira
Vakabatwa ne pHLS9 (2 mg protein / mL), 25 μg/mL Alamethicin (UGT reaction musanganiswa B), 90 mM phosphate buffer (pH 7.4), 2.5 mM mg 2+, 2.5 mM isocitrate, uye 0.6 mM pa37° C NADP +, 0.9 U/mL isocitrate dehydrogenase, 100 U/mL superoxide dismutase uye 0.1 mM acetyl-CoA.Zvadaro, 2.5 mM UDP-glucuronic acid (UGT reaction musanganiswa mhinduro A), 40 μM PAPS, 1.2 mM SAM, 1 mM dithiothreitol, 10 mM glutathione, uye 50 μM clobromazolam kana Bromazolam yakawedzerwa.
Rection Conditions:50 μM Bromazolam kwe360min mu37°C
Applications:Bromazolam metabolites aivakuzivikanwamu pHLS9 incubation.