Xylazine CAS NO: 7361-61-7 Rompun, Anased, Sedazine, Chanazine

Fa'aaogāga fa'afoma'i
Toluene thiazide e masani ona faʻaaogaina e fai ma sedative, faʻamalolo maso ma analgesic.E masani ona faʻaaogaina e togafitia ai le tetanus.Xylazine e tutusa lelei ma vailaʻau e pei ole phenothiazine, tricyclic antidepressants ma clonidine.I le avea ai o se vailaʻau faʻamaʻi, e masani ona faʻaaogaina faʻatasi ma le ketamine.O le Xylazine e foliga mai e faʻaitiitia ai le lagona o le tino i le inisalini ma le kulukose.O le Yohimbine o le alpha2 adrenergic receptor antagonist lea na faʻaaogaina e faʻaitiitia ai le kulukose i tulaga maloloina.O le Yohimbine e fa'aliliuina a'afiaga o le toluene thiazide i totonu o le falema'i pe a tu'uina i totonu o le toto pe a mae'a le toluene thiazide.

pharmacodynamics

O le Xylazine o se vailaʻau malosi ole alpha 2 adrenergic agonist.Toluene thiazide ma isi alpha2 adrenergic receptor agonists e tufatufa atu i le tino i totonu ole 30-40 minute pe a tuʻuina atu.Ona o le maualuga o le lipophilicity, toluene thiazide e faʻaosofia saʻo ai le faʻaogaina o le α2 faʻapitoa faʻapea foʻi ma le peripheral αadrenergic receptors i le tele o masini.I le avea ai o se agonist, toluene thiazide e mafua ai le faʻaitiitia o le neurotransmission o le norepinephrine ma le dopamine i le fatugalemu o le tino.E faia e ala i le faʻataʻitaʻiina o le fusifusia o le norepinephrine i autoreceptors i luga o le presynaptic surface, lea e mafua ai le faʻalavelave faʻaalia o le norepinephrine.

O le Xylazine e galue foi e avea o se inhibitor felauaiga e ala i le taofia o le felauaiga o le norepinephrine e ala i le faʻatauvaʻaina o le felauaiga o substrate.O lea, toluene thiazide matua faateleina K m ma e le afaina V max.E mafai ona tupu lenei mea e ala i fegalegaleaiga tuusaʻo ma itulagi e faʻapipiʻi ma nofoaga faʻapipiʻi faʻamaʻi.Mo se faʻataʻitaʻiga, toluene thiazide ma clonidine faʻalavelaveina le faʻaogaina o le MIBG (se faʻatusa norepinephrine) e sela neuroblastoma.Xylazine e eseese affinities mo cholinergic, serotonergic, dopaminergic, alpha1, adrenergic, H 2-histamine, ma opioid receptors.O lona fausaga vailaʻau e talitutusa lava ma le phenothiazines, tricyclic antidepressants ma clonidine.