NEUROPEPTIDE FF CAS:99566-27-5 PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE AMIDE PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2 NPFF NEUROPEPTIDE FF

NPFF Neuropeptide (FLFQPQRFa) o se mammalian aminated neuropeptide na muaʻi vavae ese mai le faiʻai o povi ma faʻaalia o se peptide faʻatonutonu tiga faʻatasi ai ma le gaioiga antiopioid i le morphine-induced analgesia.

I totonu o tagata, o le neuropeptide FF peptide o loʻo faʻapipiʻiina e le NPFF gene.E lua genes o loʻo faʻapipiʻiina ni tali eseese se lua (NPFF1 ma le NPFF2) ma lua faʻamaʻi (NPFFA ma le NPFFB) ua faʻapipiʻiina i le tele o mamame.

Neuropeptide FF (NPFF) ma RFamide e fesoʻotaʻi ma peptides e faʻaaogaina e lua muamua e fegalegaleai ma vaega laiti e lua o le G-protein-coupled receptors, le NPFF1 ma le NPFF2 subtypes, ma le vavalalata lelei ma o loʻo aʻafia i le tele o galuega faʻaletino, e pei o le cardiovascular regulation, pulea o le homone, fa'agaoioia macrophage, thermohomeostasis, ma tulafono faatonutonu tiga.

Togafitiga o le NPFFA precursor i le nofoaga autu proteolytic e tatau ona maua mai se peptide o loʻo i ai le NPFF, faʻatasi ai ma le tolu N-terminal amino acids e eseese mai ituaiga i ituaiga, ma se peptide o loʻo i ai le NPSF (SLAAPQRFa), o lona umi e faʻalagolago i ituaiga.O le NPFFB ua faʻailoaina o le mea muamua o le RFamide related peptide (RFRP, faʻapitoa foi o le GnIH o le gonadotropin-suppressing hormone), o loʻo i ai peptides o loʻo i ai LPLRFa ma peptides faʻasoa tutusa C-terminal PQRFamide motif pei NPFF, pei ole NPVF (VPNLPQRFa) tagata.

O le NPFF ma le opioid system ua faʻaalia e fegalegaleai i le tele o laʻasaga, mai amioga a manu i mole mole faʻafeiloaʻi.O le Nociception o le galuega faʻaletino e sili ona suʻesuʻeina o lenei fegalegaleaiga, ae o le taui, gaioiga, 'ai ma le manava e afaina foi.E manaʻomia opioids faʻamaʻi mo mea faʻamaʻi ole tui ole tui ole NPFF, ma o NPFF peptides e aʻafia i le faʻagasologa ole faʻapalepale faʻamaʻi / hyperalgesia faʻaosoina ile togafitiga faʻamaʻi opioid.

E pulea foi e le NPFF le numera ma le metabolism o macrophages i le tino, lea e taua mo le soifua maloloina o le tino