Hygromycin A CAS:6379-56-2 Homomycin

Fa'afeso'ota'i a'u:

Email:salesexecutive1@yeah.net

Whatsapp: + 8618931626169

Wickr:liliwang

Meatotino tau vailaau:
Pa'epa'e pa'epa'e.Fa'asa'o vaivai.E so'a fua ile vai ma le ava malosi.Faia e Streptomyces hygroscopicus.
Fa'aoga:
Hygromycin A, o se vailaau fa'ama'i ua le amana'ia, e fa'aumatia fa'ama'i e mafua ai le fa'ama'i Lyme.Na mafai ona togafitia le faʻamaʻi Lyme i isumu e aunoa ma le faʻalavelaveina o le microbiome.
Vailaau (antibiotic broad-spectrum).
Fa'amatalaga ChEBI: O se oloa fa'anatura o lo'o maua ile ituaiga Streptomyces.

O le SR 9009 o se vailaʻau faʻapitoa REV-ERB e faʻatonutonu amioga faʻasolosolo ma le metabolism;e mafai ona faʻaaogaina i togafitiga o faʻalavelave moe ma faʻamaʻi metabolic.Ose vaega ta'imua mo se vasega fou o vaila'au o le kanesa e feso'ota'i ma le uati circadian o le tino.

SR9009, e taʻua foi o Stenabolic, o se vailaʻau suʻesuʻe e avea ma agonist o REV-ERB.
REV-ERB-α ma le REV-ERB-β, e lua faʻaola faaniukilia, ei ai se sao taua i le faʻatonutonuina o le faʻaaliga o polotini autu o le uati e faʻaosoina le pao i gaioiga ma metabolism.
In vitro: O le SR9009 ma lona analog SR9011 e mafai ona fa'atupula'ia le fa'atupuina o le REV-ERB-faalagolago i le gaioiga o loʻo iloiloina i sela HEK293 e faʻaalia ai le chimaeric Gal4 DNA binding domain: REV-ERB ligand binding domain α poʻo β ma le Gal4-responsive luciferase reporter .E le gata i lea, SR9009 na maua e mafai ona taofiofia le BMAL1 messenger RNA faʻamatalaga i le HepG2 sela i se REV-ERB-α / β-faʻalagolago.
In vivo: Na togafitia isumu i se fua tasi o le SR9009, SR9011 poʻo le taavale i le circadian time 6 (CT6 (6h pe a maeʻa moli) pe a maeʻa aso 12 i D / D tulaga faʻaalia ai le maualuga o le Rev-erb-α. O le tui na mafua ai le leai o se faʻalavelave i le gaioiga o le circadian locomotor. I se faʻatusatusaga, o le faʻaaogaina o se tasi fua o le SR9009 poʻo le SR9011 na mafua ai le leiloa o le gaioiga i le taimi o le vaega pogisa. fa'atasi ai ma le kiliaina o vaila'au i lalo ifo o le 24h.